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Merck

1218005

USP

Diphenhydramine hydrochloride

United States Pharmacopeia (USP) Reference Standard

Synonym(s):

2-Diphenylmethoxy-N,N-dimethylethylamine hydrochloride, N-(2-Diphenylmethoxyethyl)-N,N-dimethylamine hydrochloride

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200 MG

CZK 10,900.00

CZK 10,900.00

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About This Item

Empirical Formula (Hill Notation):
C17H21NO · HCl
CAS Number:
147-24-0
Molecular Weight:
291.82
NACRES:
NA.24
PubChem Substance ID:
329749650
UNSPSC Code:
41116107
MDL number:
MFCD00012479

Key Documents

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grade

pharmaceutical primary standard

API family

diphenhydramine

manufacturer/tradename

USP

application(s)

pharmaceutical (small molecule)

format

neat

SMILES string

Cl[H].CN(C)CCOC(c1ccccc1)c2ccccc2

InChI

1S/C17H21NO.ClH/c1-18(2)13-14-19-17(15-9-5-3-6-10-15)16-11-7-4-8-12-16;/h3-12,17H,13-14H2,1-2H3;1H

InChI key

PCHPORCSPXIHLZ-UHFFFAOYSA-N

Gene Information

human ... HRH1(3269)

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1 of 4

This Item
D2600000BP896D3630
Diphenhydramine hydrochloride United States Pharmacopeia (USP) Reference Standard

USP

1218005

Diphenhydramine hydrochloride

Diphenhydramine hydrochloride European Pharmacopoeia (EP) Reference Standard

D2600000

Diphenhydramine hydrochloride

Diphenhydramine hydrochloride British Pharmacopoeia (BP) Reference Standard

BP896

Diphenhydramine hydrochloride

Diphenhydramine hydrochloride ≥98% (HPLC)

Sigma-Aldrich

D3630

Diphenhydramine hydrochloride

manufacturer/tradename

USP

manufacturer/tradename

EDQM

manufacturer/tradename

BP

manufacturer/tradename

-

grade

pharmaceutical primary standard

grade

pharmaceutical primary standard

grade

pharmaceutical primary standard

grade

-

format

neat

format

neat

format

neat

format

-

application(s)

pharmaceutical (small molecule)

application(s)

pharmaceutical (small molecule)

application(s)

pharmaceutical
pharmaceutical small molecule

application(s)

-

API family

diphenhydramine

API family

diphenhydramine

API family

diphenhydramine

API family

-

Gene Information

human ... HRH1(3269)

Gene Information

human ... HRH1(3269)

Gene Information

human ... HRH1(3269)

Gene Information

human ... HRH1(3269)

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Diphenhydramine hydrochloride USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:
  • Acetaminophen, Diphenhydramine Hydrochloride, and Pseudoephedrine Hydrochloride Tablets
  • Dimenhydrinate
  • Dimenhydrinate Tablets
  • Diphenhydramine and Phenylephrine Hydrochlorides Tablets
  • Diphenhydramine and Pseudoephedrine Capsules
  • Diphenhydramine Hydrochloride
  • Diphenhydramine Hydrochloride and Ibuprofen Capsules

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

Sales restrictions may apply.

comparable product

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Description
Pricing

related product

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Description
Pricing

Y0000135

Diphenhydramine impurity A, European Pharmacopoeia (EP) Reference Standard

1218016

Diphenhydramine Related Compound A, United States Pharmacopeia (USP) Reference Standard

1217909

Diphenhydramine citrate, United States Pharmacopeia (USP) Reference Standard

1424209

Methylbenzhydrol, United States Pharmacopeia (USP) Reference Standard

38682

Diphenhydramine N-oxide hydrochloride, pharmaceutical impurity standard

1051602

Benzhydrol, United States Pharmacopeia (USP) Reference Standard

1218050

Diphenhydramine N-oxide, United States Pharmacopeia (USP) Reference Standard

1218027

Diphenhydramine Related Compound B, United States Pharmacopeia (USP) Reference Standard

PHR1899

Diphenhydramine Related Compound B, Pharmaceutical Secondary Standard; Certified Reference Material

PHR1897

Diphenhydramine Impurity B, Pharmaceutical Secondary Standard; Certified Reference Material

PHR1898

Diphenhydramine N-Oxide Hydrochloride, Pharmaceutical Secondary Standard; Certified Reference Material

PHR1993

Diphenhydramine Related Compound A, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2071

Benzhydrol, Pharmaceutical Secondary Standard; Certified Reference Material

BP1119

Diphenylmethanol, British Pharmacopoeia (BP) Reference Standard

PHR2268

Diphenhydramine Citrate, pharmaceutical secondary standard, certified reference material

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

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Olabisi Oduwole et al.
The Cochrane database of systematic reviews, 12(12), CD007094-CD007094 (2014-12-24)
Cough causes concern for parents and is a major cause of outpatient visits. It can impact on quality of life, cause anxiety and affect sleep in parents and children. Several remedies, including honey, have been used to alleviate cough symptoms.
Takashi Koyanagi et al.
Xenobiotica; the fate of foreign compounds in biological systems, 44(10), 893-901 (2014-03-22)
1. The pharmacokinetics of acetaminophen (marker of gastric emptying), antipyrine (marker of hepatic metabolic activity and total body water), diazepam (lipophilic and highly distributed), diphenhydramine (hepatic blood flow-limited and alpha-1 acid glycoprotein bound) and ofloxacin (renally eliminated) were evaluated in
Makiko Kido-Nakahara et al.
The Journal of clinical investigation, 124(6), 2683-2695 (2014-05-09)
In humans, pruritus (itch) is a common but poorly understood symptom in numerous skin and systemic diseases. Endothelin 1 (ET-1) evokes histamine-independent pruritus in mammals through activation of its cognate G protein-coupled receptor endothelin A receptor (ETAR). Here, we have
Shigeru Hishinuma et al.
Biochemical pharmacology, 91(2), 231-241 (2014-07-30)
Differential binding sites for first- and second-generation antihistamines were indicated on the basis of the crystal structure of human histamine H1 receptors. In this study, we evaluated differences between the thermodynamic driving forces of first- and second-generation antihistamines for human
Jung Yeon Kim et al.
Biomedical chromatography : BMC, 29(3), 465-474 (2014-08-01)
The purpose of this study was to develop and validate an ultra-performance liquid chromatography method for simultaneous analysis of 20 antihistamines (illegal additives) in dietary supplements. The limits of detection and quantitation of the method ranged from 1.5 to 2.5
View All Related Papers

Global Trade Item Number

SKUGTIN
1218005-200MG04061838719492

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