475856

Mdivi-1

≥95% (HPLC), dynamin-related GTPases inhibitor, solid

• Synonym(s): Mitochondrial Division Inhibitor, mdivi-1, Mitochondrial Division Dnm1/Drp1 ATPase Inhibitor, 3-(2,4-Dichloro-5-methoxy-phenyl)-2-thioxo-1H-quinazolin-4-one
• Empirical Formula (Hill Notation): C₁₅H₁₀Cl₂N₂O₂S
• CAS Number: 338967-87-6
• Molecular Weight: 353.22
• UNSPSC Code: 12352200
• NACRES: NA.77
• MDL number: MFCD00974506
• Assay: ≥95% (HPLC)
• Form: solid
• Storage condition: OK to freeze, protect from light

Properties

• Product Name: Mitochondrial Division Inhibitor, mdivi-1, The Mitochondrial Division Inhibitor, mdivi-1, also referenced under CAS 338967-87-6, controls the biological activity of yeast Dnm1 and mammalian Drp1.
• Quality Segment: 100
• assay: ≥95% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze, protect from light
• color: white
• solubility: DMSO: 10 mg/mL
• shipped in: wet ice
• storage temp.: −20°C
• SMILES string: Sc1[n]([c](c3c(n1)cccc3)=O)c2c(cc(c(c2)OC)Cl)Cl
• InChI: 1S/C15H10Cl2N2O2S/c1-21-13-7-12(9(16)6-10(13)17)19-14(20)8-4-2-3-5-11(8)18-15(19)22/h2-7H,1H3,(H,18,22)
• InChI key: NZJKEVWTYMOYOR-UHFFFAOYSA-N

Description

General description

A cell-permeable quinazolinone compound that inhibits yeast (Dnm1) and mammalian (Drp1) division DRPs (dynamin-related GTPases) and effectively induces mitochondrial fusion into net-like structures (IC₅₀ = 10 and 50 M in yeast and COS cultures, respectively) in a reversible manner. Cell-free studies indicate that mdivi-1 blocks Dnm1 ATPase activity (IC₅₀<10 M) and self-assembly by an allosteric modulation-based mechanism. Mdivi-1 is shown to effectively suppress STS- as well as C8-Bid-induced MOMP (Mitochondrial Outer Membrane Permeabilization) in HeLa cultures and in cell-free murine liver mitochondria preparations, respectively, as assessed by cytochrome C release.

Packaging

Packaged under inert gas

Other Notes

Cassidy-Stone A., et al. 2008. Dev. Cell14, 193.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable