TBP
TATA box binding protein
Synonyms:
GTF2D, GTF2D1, HDL4, SCA17, TFIID
Species:
Human TBP (6908), Mouse Tbp (21374), Rat Tbp (117526), fruit fly Tbp (37476), Zebrafish tbp (368882), chicken TBP (395995), domestic cat TBP (101084200), dog TBP (611193), sheep TBP (100144760), cow TBP (516578) ...More
UniProtKB ID:
Gene ID:
- Human(6908) Summary: Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes TBP, the TATA-binding protein. A distinctive feature of TBP is a long string of glutamines in the N-terminus. This region of the protein modulates the DNA binding activity of the C terminus, and modulation of DNA binding affects the rate of transcription complex formation and initiation of transcription. The number of CAG repeats encoding the polyglutamine tract is usually 32-39, and expansion of the number of repeats increases the length of the polyglutamine string and is associated with spinocerebellar ataxia 17, a neurodegenerative disorder classified as a polyglutamine disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2010]
- Mouse(21374) TATA box binding protein
- Rat(117526) TATA box binding protein
- fruit fly(37476) TATA binding protein
- Zebrafish(368882) TATA box binding protein
- chicken(395995) TATA box binding protein
- domestic cat(101084200) TATA box binding protein
- dog(611193) TATA box binding protein
- sheep(100144760) TATA box binding protein
- cow(516578) TATA box binding protein
- domestic guinea pig(100733307) TATA box binding protein
- naked mole-rat(101702646) TATA box binding protein
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-TATA-Binding-Protein Antibody, ascites fluid, Chemicon®,
Species Reactivity
xenopus, chicken, fish, human, mouse, zebrafish
Application
immunocytochemistry
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-TATA-box-binding protein Antibody, clone SL30-3-563, clone SL30-3-563, from mouse,
Species Reactivity
human, mouse, rat
Application
ChIP
western blot
western blot
Anti-TBP from hog kidney, IgG fraction of antiserum,
Species Reactivity
bovine, dog, guinea pig, human, mouse, rabbit, rat, sheep
Application
western blot
Anti-TBP antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
western blot
western blot
Anti-TBP antibody produced in goat, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
bovine, canine, human, mouse, pig, rat
Application
ELISA
western blot
western blot