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Merck

MTNR1A

melatonin receptor 1A

Synonyms:
MEL-1A-R, MT1
Species:
UniProtKB ID:
Gene ID:
  • Human(4543) Summary: This gene encodes one of two high affinity forms of a receptor for melatonin, the primary hormone secreted by the pineal gland. This receptor is a G-protein coupled, 7-transmembrane receptor that is responsible for melatonin effects on mammalian circadian rhythm and reproductive alterations affected by day length. The receptor is an integral membrane protein that is readily detectable and localized to two specific regions of the brain. The hypothalamic suprachiasmatic nucleus appears to be involved in circadian rhythm while the hypophysial pars tuberalis may be responsible for the reproductive effects of melatonin. [provided by RefSeq, Jul 2008]
  • Mouse(17773) melatonin receptor 1A
  • Rat(114211) melatonin receptor 1A
  • dog(482904) melatonin receptor 1A
  • sheep(443022) melatonin receptor 1A
  • chicken(396319) melatonin receptor 1A
  • naked mole-rat(101719975) melatonin receptor 1A
  • domestic guinea pig(100720785) melatonin receptor 1A
  • cow(539948) melatonin receptor 1A
  • domestic cat(101098297) melatonin receptor 1A

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Small Molecule - Agonist

Product Number
Description
Species
6-Hydroxymelatonin, ,
Species
human
Ramelteon, ,
Species
human
Agomelatine, ≥98% (HPLC),
Species
human

Small Molecule - Antagonist

Product Number
Description
Species
Luzindole, ≥90%,
Species
human
Agomelatine, ≥98% (HPLC),
Species
human
Melatonin, powder, ≥98% (TLC),
Species
human

Antibodies

Product Number
Description
Species Reactivity
Application
Anti-MTNR1A antibody produced in goat, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
western blot

Small Molecule - Ligand

Product Number
Description
Species
Melatonin, powder, ≥98% (TLC),
Species
human

Small Molecule - Precursor

Product Number
Description
Species
N-Acetyl-5-hydroxytryptamine, ≥99% (HPLC), powder,
Species
human

Proteins

Product Number
Description
Species
ChemiSCREEN Membrane Preparation Recombinant Human MT1 Melatonin Receptor, ,
Species
human

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting human MTNR1A,
Species
human