IDE
insulin-degrading enzyme
Synonyms:
INSULYSIN
Species:
Human IDE (3416), Mouse Ide (15925), Rat Ide (25700), fruit fly Ide (40248), Zebrafish ide (561390), dog IDE (477768), chicken IDE (423814), sheep IDE (101104194), cow IDE (523752), Horse IDE (100071303) ...More
UniProtKB ID:
Gene ID:
- Human(3416) Summary: This gene encodes a zinc metallopeptidase that degrades intracellular insulin, and thereby terminates insulins activity, as well as participating in intercellular peptide signalling by degrading diverse peptides such as glucagon, amylin, bradykinin, and kallidin. The preferential affinity of this enzyme for insulin results in insulin-mediated inhibition of the degradation of other peptides such as beta-amyloid. Deficiencies in this protein's function are associated with Alzheimer's disease and type 2 diabetes mellitus but mutations in this gene have not been shown to be causitive for these diseases. This protein localizes primarily to the cytoplasm but in some cell types localizes to the extracellular space, cell membrane, peroxisome, and mitochondrion. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described but have not been experimentally verified.[provided by RefSeq, Sep 2009]
- Mouse(15925) insulin degrading enzyme
- Rat(25700) insulin degrading enzyme
- fruit fly(40248) Insulin degrading metalloproteinase
- Zebrafish(561390) insulin-degrading enzyme
- dog(477768) insulin-degrading enzyme
- chicken(423814) insulin-degrading enzyme
- sheep(101104194) insulin-degrading enzyme
- cow(523752) insulin-degrading enzyme
- Horse(100071303) insulin-degrading enzyme
- domestic cat(101093646) insulin-degrading enzyme
- naked mole-rat(101706921) insulin-degrading enzyme
- domestic guinea pig(100719651) insulin-degrading enzyme
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-IDE, N-Terminal (97-273) Rabbit pAb, liquid, Calbiochem®,
Species Reactivity
hamster, human, mouse, rat
Application
Anti-IDE antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry
western blot
western blot
Anti-IDE antibody produced in rabbit, ,
Species Reactivity
human, mouse
Application
immunofluorescence
western blot
western blot
Anti-IDE Antibody, clone 1J8 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Species Reactivity
human, mouse, rat
Application
affinity binding assay
immunocytochemistry
immunohistochemistry
western blot
immunocytochemistry
immunohistochemistry
western blot
Anti-Insulin-degrading enzyme (IDE) antibody produced in rabbit, ,
Species Reactivity
human, mouse, rat
Application
western blot