Home WebinarsUnlocking Bioavailability: Mesoporous Drug Carrier for Stable Amorphous Formulations

Unlocking Bioavailability: Mesoporous Drug Carrier for Stable Amorphous Formulations

WEBINAR

Drug solubility is a critical issue in formulation development, with many compounds facing risks due to poor oral bioavailability. Enhancing solubility is a major challenge for both new chemical entities and existing drugs. Mesoporous silica offers a solution by utilizing molecular adsorption and steric stabilization within its nanoconfined pores, to create stable and effective amorphous formulations. This approach is promising for improving the bioavailability of poorly soluble active pharmaceutical ingredients (APIs). The session will cover the mechanistic foundations of mesoporous silica, including lab-scale loading and scale-up potential, along with in vitro and in vivo case studies demonstrating its effectiveness for typical BCS II compounds.

In this webinar, you will learn:

An overview how mesoporous silica technology result in stable and effective amorphous formulations
Loading methods on mesoporous silica and their performance
Case studies of in vitro and in vivo performance of mesoporous silica formulations
How mesoporous silica can reduce the risk of re-crystallization of poor glass formers.

Speakers

Markus Lubda, Ph.D.

Merck

Strategic Business Manager

Markus is a biomolecular engineer. He is responsible for the strategic development and positioning of an excipient portfolio for oral solid dosage form applications. Thereby, the focus is to enhance solubility and bioavailability of the most challenging APIs with specifically engineered excipients for oral solid application. He holds a Ph.D. in biology/chemistry from the Technical University of Darmstadt and is a biomolecular engineer.

Suruchi Vishwasrao, Ph.D.

Merck

Senior Scientist

Suruchi Vishwasrao is a senior scientist at Merck's global formulation application R&D lab in Mumbai, India. She holds a doctorate in industrial pharmacy from A&M Schwartz School of Pharmacy, Long Island University, NY, USA. She has more than 14 years of pharmaceutical development experience and has expertise in formulation development of solids, semisolids, and NDDS products. Her research has been published in various national and international journals as well as in symposia. At Merck, she is focusing on formulation development, technical support, and training of solid dosage forms. She has expertise in matrix formulations, solubility enhancement techniques like hot melt extrusion, drug carrier, and development of complex generics.

Rimson Muara Jaya

Merck

Customer Application Expert SEATWO

Rimson is a technical application expert, specializing in small to large molecules. Rimson holds a pharmacist's degree and a master's in business administration. He has more than 10 years of extensive experience in the pharmaceutical industry, with a strong focus on project management, production, and GMP assurance for various small molecule pharmaceutical dosage forms.