- 3-iodothyronamine (T1AM), a novel antagonist of muscarinic receptors.
3-iodothyronamine (T1AM), a novel antagonist of muscarinic receptors.
European journal of pharmacology (2016-11-07)
Annunziatina Laurino, Rosanna Matucci, Giulio Vistoli, Laura Raimondi
PMID27815171
ANOTACE
3-iodothyronamine (T1AM) is a trace amine suspected to derive from thyroid hormone metabolism. T1AM was described as a ligand of G-protein coupled monoaminergic receptors, including trace amine associated receptors, suggesting the amine may exert a modulatory role on the monoaminergic transmission. Nothing is known on the possibility that T1AM could also modulate the cholinergic transmission interacting with muscarinic receptors. We evaluated whether T1AM (10nM-100μM) was able to i) displace [
MATERIÁLY