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SML3706

BT2

≥98% (HPLC)

Synonym(s):

3,6-Dichloro-1-benzothiophene-2-carboxylic acid, 3,6-Dichlorobenzo[b]thiophene-2-carboxylic acid, 3,6-Dichlorobenzothiophene-2-carboxylic acid

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Size/SKUAvailabilityPrice
10 mg
Please contact Customer Service for Availability
$112.00
50 mg
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$449.00

About This Item

Empirical Formula (Hill Notation):
C9H4Cl2O2S
CAS Number:
Molecular Weight:
247.10
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
powder

$112.00


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Quality Segment

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

[s]1c2c(c(c1C(=O)O)Cl)ccc(c2)Cl

InChI

1S/C9H4Cl2O2S/c10-4-1-2-5-6(3-4)14-8(7(5)11)9(12)13/h1-3H,(H,12,13)

InChI key

AAHPIJMQJAZYTM-UHFFFAOYSA-N

Biochem/physiol Actions

BT2 is an orally active, allosteric mitochondrial branched-chain α-ketoacid dehydrogenase (BCKD) kinase (BCKDK or BDK) inhibitor (IC50 = 3.19 μM) that induces BDK dissociation from the BCKD complex (BCKDC) with superior pharmacokinetics and metabolic stability than (S)-CPP. BT2 increases cellular BCKDC activity in cultures (40 μM; MEF & murine hepatocytes) and induces BDK degradation in mice & rats in vivo, effectively upregulating tissue BCKDC activity and downregulating plasma branched-chain amino acid (BCAA) level. Typical dosing range: 40-250 μM (in cultures or cell-free), 20-40 mg/kg (ip. or po. in vivo; mice & rats) or 200 mg/kg diet.
Orally active, allosteric mitochondrial branched-chain α-ketoacid dehydrogenase complex (BCKDC) kinase (BCKDK, BDK) inhibitor in vitro and in vivo.

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This Item
SML3531SML2695C0496
assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

form

powder

form

powder

form

powder

form

powder

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

room temp

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: >20 mg/mL

color

white to beige

color

white to beige

color

white to beige

color

-


Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable



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