RAB0659

Human FOLR1 / Folate Receptor Alpha ELISA Kit

• NACRES: NA.84
• UNSPSC Code: 41116158
• Gene information: human ... FOLR1(2348)
• Input: sample type cell culture supernatant(s); sample type plasma; sample type serum
• Species reactivity: human
• Storage temp.: −20°C
• Shipped in: wet ice

Properties

• species reactivity: human
• packaging: kit of 96 wells (12 strips x 8 wells)
• technique(s): ELISA: suitable
• input: sample type cell culture supernatant(s); sample type plasma; sample type serum
• assay range: inter-assay cv: <12%; intra-assay cv: <10%; sensitivity: 0.1 ng/mL; standard curve range: 0.102-25 ng/mL
• detection method: colorimetric
• shipped in: wet ice
• storage temp.: −20°C
• Gene Information: human ... FOLR1(2348)

Description

General description

The antibody pair provided in this kit recognizes human Folate Receptor Alpha.
The folate receptor 1 (FOLR1) gene is mapped to human chromosome 11q13.4. The gene codes for a glycosylphosphatidylinositol protein that is attached to cell membranes. Folr1 is expressed in placenta, kidney tubules and choroid plexus.

Application

For research use only. Not for use in diagnostic procedures.
Please refer to the attached General ELISA KIT Procedure (sandwich, competitive & Indirect ELISA)

Biochem/physiol Actions

Folate receptor 1 (FOLR1) plays a vital role in folate transport across the blood–brain barrier through the choroid plexus. It is also essential for neural tube closure during embryogenesis. Mutation in the gene leads to the development of cerebral folate deficiency in a few families. Overexpression of the gene has been observed in some epithelial malignancies including medulloblastoma, ovarian, lung and breast carcinomas. FOLR1 acts as a potential biomarker and therapeutic target for medulloblastoma.

Kit Components Also Available Separately

• RABTMB3

  ELISA Colorimetric TMB Reagent (HRP Substrate, Item H)

  SDS
• RABSTOP3

  ELISA Stop Solution (Item I)

  SDS
• RABWASH4

  20X Wash Buffer (Item B)

  SDS

Safety Information

• pictograms: GHS05
• signalword: Warning
• hcodes: H290
• pcodes: P234 - P390
• Hazard Classifications: Met. Corr. 1
• Storage Class: 12 - Non Combustible Liquids
• flash_point_f: Not applicable
• flash_point_c: Not applicable