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Key Documents

P2254

Sigma-Aldrich

Poly-L-proline

suitable for ligand binding assays, Mol wt 1,000-10,000

Synonyma:

L-Proline homopolymer

Přihlásitk zobrazení cen stanovených pro organizaci a smluvních cen


About This Item

Empirický vzorec (Hillův zápis):
C5H9NO2
Číslo CAS:
Molekulová hmotnost:
115.13
MDL number:
UNSPSC Code:
12352209
PubChem Substance ID:
NACRES:
NA.26

product name

Poly-L-proline, mol wt 1,000-10,000

form

powder

Quality Level

mol wt

1,000-10,000

technique(s)

ligand binding assay: suitable

color

white

storage temp.

−20°C

SMILES string

OC(=O)C1CCCN1

InChI

1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)

InChI key

ONIBWKKTOPOVIA-UHFFFAOYSA-N

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Application


  • Highly sensitive and selective electrochemical sensor for simultaneous determination of gallic acid, theophylline and caffeine using poly(l-proline) decorated carbon nanotubes in biological and food samples.: This study presents an innovative electrochemical sensor that utilizes poly-L-proline decorated carbon nanotubes for the simultaneous detection of gallic acid, theophylline, and caffeine. This sensor demonstrates high sensitivity and selectivity, making it suitable for applications in both biological and food samples (Aschemacher NA et al., 2024).

  • Water-assisted and protein-initiated fast and controlled ring-opening polymerization of proline N-carboxyanhydride.: This research explores the water-assisted and protein-initiated ring-opening polymerization of proline N-carboxyanhydride, leading to the rapid and controlled synthesis of poly-L-proline. The study highlights the method′s efficiency and potential for producing high-quality poly-L-proline for various applications (Hu Y et al., 2022).

  • Phosphorylation of the actin-binding protein profilin2a at S137 modulates bidirectional structural plasticity at dendritic spines.: This study examines the role of poly-L-proline regions in the actin-binding protein profilin2a, specifically focusing on its phosphorylation at S137. The findings reveal how these modifications impact the structural plasticity of dendritic spines, providing insights into neuronal function and plasticity (Cornelius J et al., 2023).

  • A structural model of the profilin-formin pacemaker system for actin filament elongation.: This paper presents a structural model involving poly-L-proline regions within the profilin-formin complex, which acts as a pacemaker for actin filament elongation. The study offers a detailed understanding of the molecular mechanisms driving actin dynamics and cellular movement (Schutt CE et al., 2022).

Biochem/physiol Actions

Poly-L-Proline is an antigenic homopolymer.

Analysis Note

Molecular weight based on viscosity.

Other Notes

For additional technical information on polyamino acids please visit the Polyamino acid FAQ resource.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


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Profilins are the key regulators of actin dynamics in all eukaryotic cells. However, little information is available on their biochemical properties and functions in kinetoplastids, such as Trypanosoma and Leishmania. We show here that Leishmania parasites express only one homolog
Xing Zhang et al.
Physical chemistry chemical physics : PCCP, 14(47), 16243-16249 (2012-11-01)
Polyproline is a fascinating polymer with interesting structural properties that have been studied in both solution and the gas phase. Herein, a method capable of measuring structural dynamics over long timescales is developed and applied to examination of polyproline in
Christopher J Woolstenhulme et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(10), E878-E887 (2013-02-23)
Although the ribosome is a very general catalyst, it cannot synthesize all protein sequences equally well. For example, ribosomes stall on the secretion monitor (SecM) leader peptide to regulate expression of a downstream gene. Using a genetic selection in Escherichia
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c-Src is a non-receptor tyrosine kinase involved in numerous signal transduction pathways. The kinase, SH3 and SH2 domains of c-Src are attached to the membrane-anchoring SH4 domain through the flexible Unique domain. Here we show intra- and intermolecular interactions involving
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Proceedings of the National Academy of Sciences of the United States of America, 110(36), 14610-14615 (2013-07-31)
Huntington disease (HD) is a neurodegenerative disorder caused by a CAG expansion within the huntingtin gene that encodes a polymorphic glutamine tract at the amino terminus of the huntingtin protein. HD is one of nine polyglutamine expansion diseases. The clinical

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Humankind has utilized protein materials throughout its existence, starting with the use of materials such as wool and silk for warmth and protection from the elements and continuing with the use of recombinant DNA techniques to synthesize proteins with unique and useful properties.

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