I5403

Insulin-Like Growth Factor Binding Protein-2 human

recombinant, expressed in NSO cells, lyophilized powder, suitable for cell culture, ≥95% (SDS-PAGE)

• Synonym(s): IGFBP-2
• UNSPSC Code: 51111800
• NACRES: NA.32
• MDL number: MFCD02099094

Properties

• biological source: human
• Quality Segment: 100
• recombinant: expressed in NSO cells
• assay: ≥95% (SDS-PAGE)
• form: lyophilized powder
• potency: 0.04 μg/mL
• mol wt: ~36 kDa by SDS-PAGE, calculated mol wt ~31 kDa
• packaging: pkg of 25 μg
• storage condition: avoid repeated freeze/thaw cycles
• technique(s): cell culture | mammalian: suitable
• impurities: endotoxin, tested
• UniProt accession no.: P18065
• storage temp.: −20°C
• Gene Information: human ... IGFBP2(3485)

Description

General description

The gene IGFBP-2 (insulin-like growth factor binding protein-2) is mapped to human chromosome 2q35.[1]

Biochem/physiol Actions

During development, insulin-like growth factor binding protein-2 is expressed in a number of tissues with the highest expression level found in the central nervous system. IGFBP-2 exhibits a 2-10 fold higher affinity for IGF II than for IGF I. Mouse and human IGFBP-2 share approximately 82% homology.

Exhibits a 2-10 fold higher affinity for IGF II than for IGF I.

IGFBP-2 (insulin-like growth factor binding protein-2) regulates the function of IGF ligands. IGFBP2 is associated with skeletal muscle cell proliferation and differentiation. It also plays an important role in the differentiation of corneal fibroblast.[2]

Physical form

Lyophilized from a 0.2 μm filtered solution of 30% (v/v) acetonitrile with 0.1% (v/v) TFA

Analysis Note

The biological activity is measured by its ability to inhibit recombinant human lGF-II on MCF-7 cells.

Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H319,H332
• pcodes: P261 - P264 - P271 - P280 - P304 + P340 + P312 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Inhalation - Eye Irrit. 2
• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves