Hlavní dokumenty

Zobrazit celou dokumentaci

C0832

Clozapine N-oxide

Name: Clozapine N-oxide
Brand: SIGMA

≥98% (HPLC), solid, 5-HT₂ serotonin receptor antagonist

Synonyma:

8-Chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo[b,e](1,4)diazepine N-oxide

Přihlásit pro zobrazení organizačních a smluvních cen.

Vybrat velikost

Změnit zobrazení

O této položce

Empirický vzorec (Hillův zápis):

C₁₈H₁₉ClN₄O

Číslo CAS:

34233-69-7

Molekulová hmotnost:

342.82

UNSPSC Code:

12352119

PubChem Substance ID:

24892276

NACRES:

NA.77

MDL number:

MFCD00210190

Form:

solid

Technický servis

Potřebujete pomoc? Náš tým zkušených odborníků je vám k dispozici.

Dovolte nám, abychom vám pomohli

Vlastnosti

Název produktu

Clozapine N-oxide,

form

solid

Quality Segment

200

SMILES string

C[N+]1([O-])CCN(CC1)C2=Nc3cc(Cl)ccc3Nc4ccccc24

InChI

1S/C18H19ClN4O/c1-23(24)10-8-22(9-11-23)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h2-7,12,20H,8-11H2,1H3

InChI key

OGUCZBIQSYYWEF-UHFFFAOYSA-N

Popis

General description

Clozapine N-oxide (CNO), inactive from of clozapine drug, activates G-protein-coupled receptors (GPCRs). CNO serves as a synthetic ligand for engineered human muscarinic receptor. It elicits clozapine-like effects upon metabolic conversion. Clozapine conversion to CNO favors its passage through blood-brain barrier.

Application

Clozapine N-oxide has been used:

for the activation of human M4 muscarinic (hM4Di) in primary motor cortex
for inducing in vivo chemogenetic manipulation and impairing locomotor activity in Th-cre transgenic mice
in behavioral testing in mice and for stimulating (HEK293) cells

Biochem/physiol Actions

5-HT₂ serotonin receptor antagonist; major metabolite of clopazine that can be monitored by HPLC.

5-HT₂ serotonin receptor antagonist; major metabolite of clopazine.

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

pictograms

GHS06

signalword

Danger

hcodes

H301,H336

pcodes

P301 + P310 + P330

Hazard Classifications

Acute Tox. 3 Oral - STOT SE 3

target_organs

Central nervous system

Skladovací třída

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c