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A4599

SAFC

L-Arginine monohydrochloride

Farmaceutická výroba

Synonyma:

(S)-(+)-2-Amino-5-[(aminoiminomethyl)amino]pentanoic acid monohydrochloride, (S)-(+)-Arginine hydrochloride

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About This Item

Empirický vzorec (Hillův zápis):
C6H14N4O2 · HCl
Číslo CAS:
1119-34-2
Molekulová hmotnost:
210.66
Beilstein/REAXYS Number:
3631658
EC Number:
214-275-1
MDL number:
MFCD00064550
UNSPSC Code:
12352209
NACRES:
NA.26

biological source

non-animal source

Quality Level

400

assay

≥98.5%

form

crystalline powder

technique(s)

cell culture | mammalian: suitable

impurities

endotoxin, heavy metals, residual solvents, tested

solubility

H2O: 100 mg/mL

density

1.42 g/cm3 at 20 °C

anion traces

chloride (Cl-): 16.58-17.00%
sulfate (SO42-): ≤0.020%

cation traces

As: ≤1.0 ppm
NH4+: ≤0.02%
heavy metals: ≤10 ppm

application(s)

pharmaceutical (small molecule)

foreign activity

cytotoxicity, tested

SMILES string

Cl[H].N[C@@H](CCCNC(N)=N)C(O)=O

InChI

1S/C6H14N4O2.ClH/c7-4(5(11)12)2-1-3-10-6(8)9;/h4H,1-3,7H2,(H,11,12)(H4,8,9,10);1H/t4-;/m0./s1

InChI key

KWTQSFXGGICVPE-WCCKRBBISA-N

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Související kategorie

General description

Our SAFC® portfolio of high-quality raw materials for use in biopharmaceutical processing withstands strict quality control procedures plus the documentation and expertise to help our customers meet requirements as defined by the M-Clarity Program.

M-Clarity Program

Our comprehensive portfolio of upstream process chemicals not only provides biopharmaceutical manufacturers with high-quality raw materials for production of classical and novel therapies, but also helps them get to market faster and simplify regulatory challenges. Trust us to deliver supply chain transparency and reliable sourcing around the globe, streamlining your product qualification with best-in-class regulatory support and service.
To request documentation for this product, please contact Customer Support and select ‘Product Documentation′. Please note that access to the documentation for this product requires a confidentiality disclosure agreement.

Application

L-Arginine is a non-essential amino acid. It is used as a cell culture media component for the commercial biomanufacture of therapeutic recombinant proteins and monoclonal antibodies. L-Arginine monohydrochloride is a modified version of L-Arginine with improved solubility.

Biochem/physiol Actions

Substrate of nitric oxide synthase, which is converted to citrulline and nitric oxide (NO). Induces insulin release by a nitric oxide-dependent mechanism.

Legal Information

SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Osvědčení o analýze (COA)

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L-Arginine monohydrochloride certified reference material, TraceCERT®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland

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L-Arginine EMPROVE® EXPERT, Ph. Eur., ChP, JP, USP

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Arginine hydrochloride United States Pharmacopeia (USP) Reference Standard

USP

1042601

Arginine hydrochloride

Arginine hydrochloride British Pharmacopoeia (BP) Reference Standard

BP694

Arginine hydrochloride

L-Arginine from non-animal source, meets EP, USP testing specifications, suitable for cell culture, 98.5-101.0%

Sigma-Aldrich

A8094

L-Arginine

L-Arginine, Hydrochloride

Millipore

181003

L-Arginine, Hydrochloride

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Endocrine, 49(2), 492-502 (2014-11-10)
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C B Christiansen et al.
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Relative hypovolemia is frequently found in early stages of severe sepsis and septic shock and prompt and aggressive fluid therapy has become standard of care improving tissue perfusion and patient outcome. This paper investigates the role of the nitric oxide
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Phenotype switching is commonly observed in nature. This prevalence has allowed the elucidation of a number of underlying molecular mechanisms. However, little is known about how phenotypic switches arise and function in their early evolutionary stages. The first opportunity to
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