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D2955000

Domperidone

European Pharmacopoeia (EP) Reference Standard

Synonyma:

4-(5-Chloro-2-oxo-1-benzimidazolinyl)-1-[3-(2-oxobenzimidazolinyl)propyl]piperidine

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About This Item

Empirický vzorec (Hillův zápis):
C22H24ClN5O2
Číslo CAS:
57808-66-9
Molekulová hmotnost:
425.91
MDL number:
MFCD00069256
UNSPSC Code:
41116107
PubChem Substance ID:
329798765
NACRES:
NA.24

grade

pharmaceutical primary standard

API family

domperidone

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

SMILES string

Clc1ccc2N(C3CCN(CCCN4C(=O)Nc5ccccc45)CC3)C(=O)Nc2c1

InChI

1S/C22H24ClN5O2/c23-15-6-7-20-18(14-15)25-22(30)28(20)16-8-12-26(13-9-16)10-3-11-27-19-5-2-1-4-17(19)24-21(27)29/h1-2,4-7,14,16H,3,8-13H2,(H,24,29)(H,25,30)

InChI key

FGXWKSZFVQUSTL-UHFFFAOYSA-N

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General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Domperidone EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

related product

Č. produktu
Popis
Stanovení ceny

pictograms

Health hazard
GHS08

signalword

Warning

hcodes

H361fd

Hazard Classifications

Repr. 2

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

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Osvědčení o analýze (COA)

Lot/Batch Number

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Sigma-Aldrich

22140

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Domperidone.
M C Champion
General pharmacology, 19(4), 499-505 (1988-01-01)
Savio C Reddymasu et al.
The American journal of gastroenterology, 102(9), 2036-2045 (2007-05-10)
Domperidone is a dopamine-2 receptor antagonist. It acts as an antiemetic and a prokinetic agent through its effects on the chemoreceptor trigger zone and motor function of the stomach and small intestine. Unlike metoclopramide, it does not cause any adverse
R N Brogden et al.
Drugs, 24(5), 360-400 (1982-11-01)
Domperidone is a dopamine antagonist that does not readily enter the central nervous system. Given parenterally or orally it increases gastric emptying of liquids and increases lower oesophageal sphincter pressure in healthy subjects. The antiemetic and pharmacodynamic profile of domperidone
Badriul Hegar et al.
The Turkish journal of pediatrics, 55(1), 1-7 (2013-05-23)
Gastroesophageal reflux (GER) is a normal physiologic process occurring several times per day in healthy infants. Regurgitation is defined as the passage of refluxed gastric contents into the pharynx or mouth, sometimes with expulsion out of the mouth. There are
D S Pritchard et al.
British journal of clinical pharmacology, 59(6), 725-729 (2005-06-14)
To determine whether there is robust evidence of efficacy for domperidone in reducing the symptoms of gastro-oesophageal reflux (GOR) and gastro-oesophageal reflux disease (GORD) in children. Systematic review of randomized controlled trials (RCTs). A search was made of the Cochrane
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