8.17043

Thimerosal

EMPROVE^® ESSENTIAL, Ph. Eur., BP

• Synonyma: Thimerosal
• Empirický vzorec (Hillův zápis): C₉H₉HgNaO₂S
• Číslo CAS: 54-64-8
• Molekulová hmotnost: 404.81
• MDL number: MFCD00013062
• UNSPSC Code: 12352103
• EC Index Number: 200-210-4

Vlastnosti

• agency: BP; Ph. Eur.
• Quality Level: 500
• product line: EMPROVE^® ESSENTIAL
• form: solid
• pH: 6.7 (20 °C, 10 g/L in H₂O)
• mp: 232-233 °C (decomposition)
• transition temp: flash point 250 °C
• solubility: 1000 g/L
• application(s): liquid formulation; ophthalmics; pharma/biopharma processes; pharmaceutical; semi-solid formulation
• storage temp.: 15-25°C
• SMILES string: [Hg+]CC.[Na+].[S-]c1c(cccc1)C(=O)[O-]
• InChI: 1S/C7H6O2S.C2H5.Hg.Na/c8-7(9)5-3-1-2-4-6(5)10;1-2;;/h1-4,10H,(H,8,9);1H2,2H3;;/q;;2*+1/p-2
• InChI key: RTKIYNMVFMVABJ-UHFFFAOYSA-L

Popis

General description

Finding the right excipient that matches your needs as well as regulatory demands can be a complicated challenge in formulation. With our application know-how and regulatory expertise, we support you in every step of development, scale-up, and production.
As part of our Emprove^® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC^® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Application

Thimerosal has strong antiseptic and antifungal capabilities and is therefore typically used as preservative in liquid dosage forms of cosmetics and pharmaceutical products.

Legal Information

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany

SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

As part of the corporation global plan to support the MinamataConvention in eliminating mercury-containing compounds, as of January 2021customers will be required to provide an End-Use Declaration. The sales ofthimerosal will be restricted for approved applications only, such aspreservative in vaccine manufacturing, preservative in eye cosmetics, researchuse within academia (excluding preservation intent) and as reference materialonly. The product is not intended for use as a biocide under global biocideregulations, including but not limited to US EPA′s Federal InsecticideFungicide and Rodenticide Act , European Biocidal Products Regulation, Canada’sPest Management Regulatory Agency, Turkey’s BiocidalProducts Regulation, Korea’s Consumer Chemical Products and BiocideSafety Management Act (K-BPR) and others.

For U.S. Customers: Contains mercury; Do not place in trash - dispose according to local, state, or federal laws.

Bezpečnostní informace

• pictograms: GHS06,GHS08,GHS09
• signalword: Danger
• hcodes: H300 + H310 + H330,H373,H410
• pcodes: P262 - P264 - P273 - P280 - P302 + P352 + P310 - P304 + P340 + P310
• Hazard Classifications: Acute Tox. 1 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - STOT RE 2 Oral
• target_organs: Kidney
• Storage Class: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable