5.05880

L-745,870 Trihydrochloride

• Synonyma: L-745,870 Trihydrochloride, Dopamine D₄ receptor Antagonist, L-745,870 trihydrochloride, L-745870, L745870
• Empirický vzorec (Hillův zápis): C₁₈H₁₉ClN₄ · 3HCl
• Číslo CAS: 158985-00-3
• Molekulová hmotnost: 436.21
• MDL number: MFCD00932830
• UNSPSC Code: 12352200
• NACRES: NA.77

Vlastnosti

• assay: ≥99% (HPLC)
• Quality Segment: 100
• form: solid
• potency: 0.4 nM K_i
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze, protect from light
• color: off-white
• solubility: water: soluble
• storage temp.: 2-8°C
• SMILES string: Clc1ccc(cc1)N2CCN(CC2)Cc3c4c([nH]c3)nccc4
• InChI: 1S/C18H19ClN4/c19-15-3-5-16(6-4-15)23-10-8-22(9-11-23)13-14-12-21-18-17(14)2-1-7-20-18/h1-7,12H,8-11,13H2,(H,20,21)
• InChI key: OGJGQVFWEPNYSB-UHFFFAOYSA-N

Popis

General description

Selective D₄ receptor antagonist with excellent brain penetration. Displays an affinity (K_i) of 0.4 nM for human D₄ receptors with >1000-fold binding selectivity over D₂ and D₃ receptors. Does not block agonist-induced activation of GIRK currents. It is used frequently in retinal and CNS studies of D₄ modulation.

Biochem/physiol Actions

Primary Target
D₄

Reversible: yes

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Li, H. et al., 2013. J. Neurosci.33, 3135.

Pillai, G. et al. 1998. Neuropharmacol.337, 983.
Kulagowski, J. et al. 1996. J. Med. Chem.39, 1941.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Bezpečnostní informace

• Skladovací třída: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable