These products are for research use only and have not been evaluated for in vivo applications. To assess potential differences between this product and M3262, it is recommended to consult the Certificates of Analysis: https://www.sigmaaldrich.com/product/mm/454575#product-documentation and https://www.sigmaaldrich.com/product/sigma/m3262#product-documentation
454575
N-Methyl-D-aspartic Acid hydrate
>95% (TLC), solid, excitatory amino acid neurotransmitter, Calbiochem®
Synonym(s):
N-Methyl-D-aspartic Acid, Hydrate, NMDA
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| Size/SKU | Availability | Price |
|---|---|---|
100 mg | Check Cart for Availability | $373.00 |
About This Item
Empirical Formula (Hill Notation):
C5H9NO4 · xH2O
CAS Number:
Molecular Weight:
147.13 (anhydrous basis)
UNSPSC Code:
12352209
NACRES:
NA.77
MDL number:
Assay:
>95% (TLC)
Form:
solid
Storage condition:
OK to freeze
Product Name
N-Methyl-D-aspartic Acid, Hydrate, Excitatory amino acid neurotransmitter.
Quality Segment
description
Merck USA index - 14, 6662
assay
>95% (TLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
color
white
solubility
water: 1 mg/mL
shipped in
ambient
storage temp.
10-30°C
SMILES string
N([C@H](CC(=O)O)C(=O)[O-])C
InChI
1S/C5H9NO4/c1-6-3(5(9)10)2-4(7)8/h3,6H,2H2,1H3,(H,7,8)(H,9,10)/p-1/t3-/m1/s1
InChI key
HOKKHZGPKSLGJE-GSVOUGTGSA-M
General description
An excitatory amino acid neurotransmitter. Selective agonist of the glutamate receptor that regulates Ca2+ channels. Important in long-term potentiation, ischemia, and epilepsy. NMDA receptors are involved in the "fine tuning" of synaptic connections in the developing brain. Chronic treatment with NMDA produces structural changes in synaptic morphology. Over-excitation of NMDA receptors causes neuronal degeneration and cell death.
Excitatory amino acid neurotransmitter. Selective agonist of the glutamate receptor that regulates Ca2+ channels. Important in long-term potentiation, ischemia, and epilepsy. NMDA receptors are involved in the "fine tuning" of synaptic connections in the developing brain. Chronic treatment with NMDA produces structural changes in synaptic morphology. Over-excitation of NMDA receptors causes neuronal degeneration and cell death.
Biochem/physiol Actions
Cell permeable: no
Primary Target
Glutamate receptor that regulates Ca2+ channels
Glutamate receptor that regulates Ca2+ channels
Product does not compete with ATP.
Reversible: no
Preparation Note
Following reconstitution, store in the refrigerator (4°C). Stock solutions are stable for several days at 4°C.
Other Notes
Mattson, M.P., et al. 1993. J. Neurosci. 13, 4575.
Yen, L-H., et al. 1993. J. Neurosci. 13, 4949.
Swann, J.W., et al. 1992. Epilepsy Res. Suppl. 9, 115.
Yen, L-H., et al. 1993. J. Neurosci. 13, 4949.
Swann, J.W., et al. 1992. Epilepsy Res. Suppl. 9, 115.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
1 of 1
This Item | |||
|---|---|---|---|
| assay >95% (TLC) | assay ≥97% (HPLC) | assay ≥95% (HPLC) | assay ≥99% (TLC) |
| form solid | form solid | form solid | form solid |
| manufacturer/tradename Calbiochem® | manufacturer/tradename Calbiochem® | manufacturer/tradename Calbiochem® | manufacturer/tradename Calbiochem® |
| Quality Level 100 | Quality Level 100 | Quality Level 100 | Quality Level 300 |
| storage temp. 10-30°C | storage temp. 2-8°C | storage temp. 10-30°C | storage temp. 10-30°C |
| solubility water: 1 mg/mL | solubility dilute aqueous base: 1 mg/mL, water: 1 mg/mL | solubility 0.1 M NaOH: 10 mg/mL, ethanol: soluble | solubility water: soluble |
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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What's the difference between CAS Number: 6384-92-5 and CAS Number:454575? (They are both NMDA). Which are applicable to be used in a NMDA lesion surgery?
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