420136

JNK Inhibitor IX

≥95% (HPLC), JNK2 and JNK3 inhibitor, solid

• Synonym(s): JNK Inhibitor IX, N-(3-Cyano-4,5,6,7-tetrahydro-1-benzothien-2-yl)-1-naphthamide
• Empirical Formula (Hill Notation): C₂₀H₁₆N₂OS · xH₂O
• CAS Number: 312917-14-9
• Molecular Weight: 332.42 (anhydrous basis)
• MDL number: MFCD01005305
• UNSPSC Code: 12352200
• NACRES: NA.77
• Assay: ≥95% (HPLC)
• Form: solid
• Storage condition: OK to freeze, protect from light

Properties

• Product Name: JNK Inhibitor IX, The JNK Inhibitor IX, also referenced under CAS 312917-14-9, controls the biological activity of JNK. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
• Quality Segment: 100
• assay: ≥95% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze, protect from light
• color: tan
• solubility: DMSO: 10 mg/mL
• shipped in: ambient
• storage temp.: 2-8°C
• SMILES string: [s]1c2c(c(c1NC(=O)c3c4c(ccc3)cccc4)C#N)CCCC2
• InChI: 1S/C20H16N2OS/c21-12-17-15-9-3-4-11-18(15)24-20(17)22-19(23)16-10-5-7-13-6-1-2-8-14(13)16/h1-2,5-8,10H,3-4,9,11H2,(H,22,23)
• InChI key: WQGDQGAFSDMBLA-UHFFFAOYSA-N

Description

General description

A thienylnaphthamide compound that acts as a potent and ATP binding site-targeting inhibitor of JNK2 and JNK3 (pIC₅₀ = 6.5 and 6.7, respectively) with little or no activity against JNK1, p38α, and a panel of more than 30 other kinases (pIC₅₀<5.0). In contrast, SP600125 offers little selectivity between JNK1 and JNK3 (pIC₅₀ = 6.4 and 5.9, respectively) under the same assay conditions.

Biochem/physiol Actions

Cell permeable: no

Primary Target
JNK2 and JNK3

Product competes with ATP.

Reversible: no

pIC50 = 6.5 and 6.7, against JNK2 and JNK3, respectively

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Angell, R.M., et al. 2007. Bioorg. Med. Chem. Lett.17, 1296.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Irritant (B)

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable