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Key Documents

07-631

Sigma-Aldrich

Anti-cdk2 Antibody

Upstate®, from rabbit

Synonyma:

Anti-CDKN2, Anti-p33(CDK2)

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

rabbit

Quality Level

100

antibody form

purified antibody

antibody product type

primary antibodies

clone

polyclonal

species reactivity

human

manufacturer/tradename

Upstate®

technique(s)

immunoprecipitation (IP): suitable
western blot: suitable

isotype

IgG

NCBI accession no.

NM_001798

UniProt accession no.

P24941

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... CDK2AP1(8099)

Specificity

Predicted to cross-react with mouse, rat, non-human primates, and hamster based on sequence homology
Recognizes human p33cdk2 protein kinase.

Immunogen

peptide corresponding to amino acids 287-298 (C-QDVTKPVPHLRL) of human cdk2

Application

Anti-cdk2 Antibody is a high quality Rabbit Polyclonal Antibody for the detection of cdk2 & has been validated in IP & WB.

Quality

routinely evaluated by immunoblot in nuclear extracts from HeLa cells

Target description

33 kDa

Physical form

Format: Purified

Analysis Note

Control
Colon tissue

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

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recommended

Č. produktu
Popis
Stanovení ceny

Storage Class

10 - Combustible liquids

wgk_germany

WGK 1

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The combination of CDK4/6 inhibitors with antiestrogen therapies significantly improves clinical outcomes in ER-positive advanced breast cancer. To identify mechanisms of acquired resistance, we analyzed serial biopsies and rapid autopsies from patients treated with the combination of the CDK4/6 inhibitor
Sublytic complement attack induces cell cycle in oligodendrocytes.
Rus, H G, et al.
Journal of immunology (Baltimore, Md. : 1950), 156, 4892-4900 (1996)
S J Elledge et al.
The EMBO journal, 10(9), 2653-2659 (1991-09-01)
The onset of S-phase and M-phase in both Schizosaccharomyces pombe and Saccharomyces cerevisiae requires the function of the cdc2/CDC28 gene product, p34, a serine-threonine protein kinase. A human homolog, p34cdc2, was identified by functional complementation of the S.pombe cdc2 mutation
Sonya Hui et al.
Circulation research, 108(9), 1053-1062 (2011-03-05)
Cell cycle progression in vascular smooth muscle cells (VSMCs) is a therapeutic target for restenosis. Having discovered that calmodulin (CaM)-dependent cyclin E/CDK2 activity underlies Ca(2+)-sensitive G(1)-to-S phase transitions in VSMCs, we sought to explore the physiological importance of the CaM-cyclin
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The Journal of biological chemistry, 272(16), 10777-10783 (1997-04-18)
Platelet-derived growth factor (PDGF) and serum, but not epidermal growth factor (EGF), stimulated sphingosine kinase activity in Swiss 3T3 fibroblasts and increased intracellular concentrations of sphingosine 1-phosphate (SPP), a sphingolipid second messenger (Olivera, A., and Spiegel, S. (1993) Nature 365
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