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918628

Sigma-Aldrich

Low endotoxin GelMA

gel strength 300 (Bloom), degree of substitution 80%, GelMA Type B

Synonyma:

GelMA, Gelatin methacrylamide, Gelatin methacrylate, Gelatin methacryloyl

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About This Item

UNSPSC Code:
12352202
NACRES:
NA.23

Quality Level

100

form

(Powder or Chunk(s) or Fibers )

impurities

<10 CFU/g Bioburden
<125 EU/g Endotoxin

color

white to pale yellow

storage temp.

2-8°C

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Související kategorie

Application

This product is low endotoxin version GelMA and ready to be used in biomedical applications.
GelMA can be used to form hydrogels for tissue engineering and 3D bioprinting. Gelatin methacryloyl (GelMA) is a polymerizable hydrogel material derived from natural extracellular matrix (ECM) components. Due to its low cost, abundance, and retention of natural cell binding motifs, gelatin has become a highly sought material for tissue engineering applications. The addition of photocrosslinkable methacrylamide functional groups in GelMA allows the synthesis of biocompatible, biodegradable, and non-immunogenic hydrogels that are stable in biologically relevant conditions and promote cell adhesion, spreading, and proliferation.

Packaging

500 mg in glass bottle

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Xin Zhao et al.
Advanced healthcare materials, 5(1), 108-118 (2015-04-17)
Natural hydrogels are promising scaffolds to engineer epidermis. Currently, natural hydrogels used to support epidermal regeneration are mainly collagen- or gelatin-based, which mimic the natural dermal extracellular matrix but often suffer from insufficient and uncontrollable mechanical and degradation properties. In
Kristel W M Boere et al.
Acta biomaterialia, 10(6), 2602-2611 (2014-03-05)
Hydrogels can provide a suitable environment for tissue formation by embedded cells, which makes them suitable for applications in regenerative medicine. However, hydrogels possess only limited mechanical strength, and must therefore be reinforced for applications in load-bearing conditions. In most
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Hydrogels are often employed as temporary platforms for cell proliferation and tissue organization in vitro. Researchers have incorporated photodegradable moieties into synthetic polymeric hydrogels as a means of achieving spatiotemporal control over material properties. In this study protein-based photodegradable hydrogels
Preparation and characterization of gelatin-poly(methacrylic acid) interpenetrating polymeric network hydrogels as a pH-sensitive delivery system for glipizide.
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Biomaterials, 31(21), 5536-5544 (2010-04-27)
The cellular microenvironment plays an integral role in improving the function of microengineered tissues. Control of the microarchitecture in engineered tissues can be achieved through photopatterning of cell-laden hydrogels. However, despite high pattern fidelity of photopolymerizable hydrogels, many such materials
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