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361518

Sigma-Aldrich

1-Hydroxypyrene

98%

Synonyma:

1-Pyrenol

Přihlásitk zobrazení cen stanovených pro organizaci a smluvních cen
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About This Item

Empirický vzorec (Hillův zápis):
C16H10O
Číslo CAS:
5315-79-7
Molekulová hmotnost:
218.25
MDL number:
MFCD00044543
UNSPSC Code:
12352100
PubChem Substance ID:
24862229
NACRES:
NA.22

assay

98%

mp

179-182 °C (lit.)

SMILES string

Oc1ccc2ccc3cccc4ccc1c2c34

InChI

1S/C16H10O/c17-14-9-7-12-5-4-10-2-1-3-11-6-8-13(14)16(12)15(10)11/h1-9,17H

InChI key

BIJNHUAPTJVVNQ-UHFFFAOYSA-N

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General description

1-Hydroxypyrene, as a urinary metabolite, is a marker of polycyclic aromatic hydrocarbons (PAH) exposure. 1-Hydroxypyrene is an important biomarker of exposure to pyrene.

Application

1-Hydroxypyrene is suitable for use in following studies:
  • To investigate the fast detection and quantification of 1-hydroxypyrene in tissue extracts from Nereis diversicolor exposed to sediment-associated pyrene by a simple fluorometric method.
  • To investigate the effects of genetic polymorphisms of the cytochrome P450 1A1 (CYP1A1) and 2E1 (CYP2E1) and glutathione S-transferases mu (GSTM1) and theta (GSTT1) on urinary 1-hydroxypyrene and 2-naphthol levels in aircraft maintenance workers.
  • To examine the the PAH exposure of cokery workers in an Estonian oil shale processing plant.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Hueiwang Anna Jeng et al.
Journal of hazardous materials, 244-245, 436-443 (2013-01-15)
The objective of the cross-sectional study was to assess whether exposure to polycyclic aromatic hydrocarbons (PAHs) from coke oven emissions contributed to alteration of semen quality and sperm DNA integrity in nonsmoking workers. Nonsmoking coke oven workers from a steel
Jena Webb et al.
International archives of occupational and environmental health, 91(1), 105-115 (2017-09-25)
Polycyclic aromatic hydrocarbons (PAHs) are contaminants with carcinogenic effects but little is known about their presence in environments surrounding oil drilling operations and spills or exposure levels in nearby communities. The objective of this study was to characterize PAH levels
Anders M B Giessing et al.
Marine environmental research, 56(5), 599-615 (2003-08-21)
The uptake of polycyclic aromatic hydrocarbons (PAHs) by marine deposit-feeding invertebrates can be determined by screening for PAH-derived metabolites. We identified 1-hydroxypyrene as the only intermediate metabolite in tissue of four species of deposit-feeding polychaetes, Nereis diversicolor, Nereis virens, Arenicola
Gabriela Domínguez-Cortinas et al.
Environmental science and pollution research international, 20(1), 351-357 (2012-05-01)
In developing countries, the management of environmental toxicants is inadequate, thus, humans may be exposed to levels higher than normal levels (background levels). Therefore, the aim of this study was to evaluate the exposure level of Mexican children to dichlorodiphenyltrichloroethane
Christiana A Demetriou et al.
Occupational and environmental medicine, 69(9), 619-627 (2012-07-10)
The association between ambient air pollution exposure and lung cancer risk has been investigated in prospective studies and the results are generally consistent, indicating that long-term exposure to air pollution may cause lung cancer. Despite the prospective nature and consistent
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