Functional understanding of the versatile protein copper metabolism MURR1 domain 1 (COMMD1) in copper homeostasis.

Functional understanding of the versatile protein copper metabolism MURR1 domain 1 (COMMD1) in copper homeostasis.

Annals of the New York Academy of Sciences (2014-04-05)

Alina Fedoseienko, Paulina Bartuzi, Bart van de Sluis

ABSTRACT

Copper is an important cofactor in numerous biological processes in all living organisms. However, excessive copper can be extremely toxic, so it is vital that the copper level within a cell is tightly regulated. The damaging effect of copper is seen in several hereditary forms of copper toxicity in humans and animals. At present, Wilson's disease is the best-described and best-studied copper-storage disorder in humans; it is caused by mutations in the ATP7B gene. In dogs, a mutation in the COMMD1 gene has been found to be associated with copper toxicosis. Using a liver-specific Commd1 knockout mouse, the biological role of Commd1 in copper homeostasis has been confirmed. Yet, the exact mechanism by which COMMD1 regulates copper homeostasis is still unknown. Here, we give an overview of the current knowledge and perspectives on the molecular function of COMMD1 in copper homeostasis.

MATERIALS

Product Number

Brand

Product Description

BCR058

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12816

Sigma-Aldrich

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326488

Sigma-Aldrich

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349208

Sigma-Aldrich

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349216

Sigma-Aldrich

Copper, wire, diam. 1.0 mm, ≥99.9%

349151

Sigma-Aldrich

Copper, foil, thickness 0.5 mm, 99.98% trace metals basis

349224

Sigma-Aldrich

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326410

Sigma-Aldrich

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254177

Sigma-Aldrich

Copper, beads, 2-8 mm, 99.9995% trace metals basis

266744

Sigma-Aldrich

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326429

Sigma-Aldrich

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207780

Sigma-Aldrich

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61139

Sigma-Aldrich

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GF00529040

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GF92323166

Copper, microfoil, disks, 25mm, thinness 0.25μm, specific density 219.9μg/cm², permanent mylar 3.5μm support, 99.99+%

GF27429891

Copper, rod, 100mm, diameter 6.35mm, as drawn, 99.999%

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Copper, rod, 50mm, diameter 12.7mm, as drawn, 99.99+%

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Copper, rod, 100mm, diameter 16mm, as drawn, 99.99+%

GF94832208

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GF16694006

Copper, rod, 50mm, diameter 6.35mm, as drawn, 99.999%

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