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  • Is there a role for subcutaneous furosemide in the community and hospice management of end-stage heart failure?

Is there a role for subcutaneous furosemide in the community and hospice management of end-stage heart failure?

Palliative medicine (2011-03-15)
Hannah Zacharias, Janet Raw, Anne Nunn, Sharon Parsons, Miriam Johnson
ABSTRACT

Patients with advanced chronic heart failure (CHF) can experience 'revolving door' admissions, often for parenteral diuretics, when time at home is precious. Home intravenous diuretic services are patchy. This retrospective review describes 43 consecutive episodes of continuous subcutaneous infusion of furosemide (CSCI-F) in 32 advanced CHF patients; 28 episodes aiming to correct fluid balance and prevent hospital admission and 15 aiming to prevent symptoms in the dying. Overall, 26/28 (93%) avoided hospital admission. Weight loss occurred in 20/28 (70%): a median loss of 5.6 kg [interquartile range (IQR) 0.1-8.9]). The daily dose of furosemide ranged from 40 to 250 mg. The median number of days on CSCI-F was 10.5 (range 2-48; IQR 6-13.8). Site reactions occurred in 10/43 (23%); all of which were mild except two, one of which required oral antibiotics. Symptoms were controlled in all 15 dying patients. CSCI-F for patients with advanced CHF is effective in terms of weight loss and prevention of hospital admission with the heart failure nurse specialist playing a key overall management role in selection and monitoring. As the majority of community and hospice nurses have access to and are familiar with CSCI pumps, this practice should be nationally transferable. The role in the dying patient requires further assessment.

MATERIALS
Product Number
Brand
Product Description

Supelco
Furosemide, Pharmaceutical Secondary Standard; Certified Reference Material
Furosemide, European Pharmacopoeia (EP) Reference Standard
USP
Furosemide, United States Pharmacopeia (USP) Reference Standard
Sigma-Aldrich
Furosemide
Supelco
Furosemide solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®
Furosemide for peak identification, European Pharmacopoeia (EP) Reference Standard