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Merck

The hepatic metabolism of two methylquinolines.

Carcinogenesis (1993-05-01)
C E Scharping, C C Duke, G M Holder, D Larden
ABSTRACT

The hepatic microsomal metabolism of the carcinogenic 8-methylquinoline (8MQ) and its noncarcinogenic isomer, 6-methylquinoline (6MQ), were compared for preparations from control rats and rats pretreated with phenobarbital or 3-methylcholanthrene. For each compound the alcohol was the major metabolite, constituting 50-75% of 6MQ metabolites and 60-85% of 8MQ metabolites. Three phenols for 6MQ and two for 8MQ were seen. The latter formed two dihydrodiols which constituted 1-5% of metabolites while dihydrodiol products were not identified for the nontumorigenic 6MQ. Epoxides were observed for 6MQ while 8MQ afforded an N-oxide.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
8-Methylquinoline, 97%
Pricing and availability is not currently available.
Sigma-Aldrich
6-Methylquinoline, ≥98%, FG
Pricing and availability is not currently available.
Sigma-Aldrich
6-Methylquinoline, 98%
Pricing and availability is not currently available.