PENNA

Penicillin G sodium salt

~1650 U/mg

• Synonym(s): Benzylpenicillin sodium salt
• Empirical Formula (Hill Notation): C₁₆H₁₇N₂NaO₄S
• CAS Number: 69-57-8
• Molecular Weight: 356.37
• Beilstein: 3834217
• EC Number: 200-710-2
• MDL number: MFCD00069666
• UNSPSC Code: 51283424
• PubChem Substance ID: 24899068
• NACRES: NA.85

Properties

• form: powder
• specific activity: ~1650 U/mg
• solubility: H₂O: 100 mg/mL
• antibiotic activity spectrum: Gram-negative bacteria; Gram-positive bacteria
• Mode of action: cell wall synthesis | interferes
• storage temp.: 2-8°C
• SMILES string: [Na+].[H][C@]12SC(C)(C)[C@@H](N1C(=O)[C@H]2NC(=O)Cc3ccccc3)C([O-])=O
• InChI: 1S/C16H18N2O4S.Na/c1-16(2)12(15(21)22)18-13(20)11(14(18)23-16)17-10(19)8-9-6-4-3-5-7-9;/h3-7,11-12,14H,8H2,1-2H3,(H,17,19)(H,21,22);/q;+1/p-1/t11-,12+,14-;/m1./s1
• InChI key: FCPVYOBCFFNJFS-LQDWTQKMSA-M

Description

General description

Penicillin G is a narrow spectrum antibiotic. It is effective against Streptococcus pneumoniae, groups A, B, C and G streptococci, nonenterococcal group D streptococci, viridans group streptococci, and non-penicillinase producing staphylococcus. Penicillin G contains β-lactam ring in their chemical structure.

Application

Penicillin G sodium salt has been used:

• to study the diagnostic and therapeutic implications of gentamicin-resistant Enterococcus faecalis sequence type 6 with reduced penicillin susceptibility
• in cell culture alone as well as in combination with streptomycin and other antibiotics
• to inhibit the synthesis of bacterial cell walls by inhibition of the cell wall peptidoglycan chain cross-lining

Biochem/physiol Actions

Mode of Action: Penicillin G acts by inhibiting cell wall synthesis through binding to penicillin binding proteins (PBPs), inhibiting peptidoglycan chain cross-linking.

Antimicrobial spectrum: This product is active against gram-positive and gram-negative bacteria.

Packaging

1mu,10mu,100mu

Caution

Solutions should be filter sterilized and stored at 2-8°C for 1 week or at -20°C for more lengthy periods. Solutions are stable at 37°C for 3 days. The sodium salt is soluble in H₂O at 100 mg/mL.

Other Notes

Keep container tightly closed in a dry and well-ventilated place.Product contains Penicillin

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H317
• Precautionary Statements: P261 - P272 - P280 - P302 + P352 - P333 + P313 - P362 + P364
• Hazard Classifications: Skin Sens. 1
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves