D5817

DMXAA

≥98% (HPLC), solid, apoptosis inducer

• Synonym(s): 5,6-Dimethylxanthenone-4-acetic Acid, ASA404, Vadimezan
• Empirical Formula (Hill Notation): C₁₇H₁₄O₄
• CAS Number: 117570-53-3
• Molecular Weight: 282.29
• MDL number: MFCD00870555
• UNSPSC Code: 12352200
• PubChem Substance ID: 24724464
• NACRES: NA.77

Properties

• product name: DMXAA, ≥98% (HPLC), solid
• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: solid
• color: light brown
• solubility: DMSO: soluble >10 mg/mL
• storage temp.: 2-8°C
• SMILES string: Cc1ccc2C(=O)c3cccc(CC(O)=O)c3Oc2c1C
• InChI: 1S/C17H14O4/c1-9-6-7-13-15(20)12-5-3-4-11(8-14(18)19)17(12)21-16(13)10(9)2/h3-7H,8H2,1-2H3,(H,18,19)
• InChI key: XGOYIMQSIKSOBS-UHFFFAOYSA-N

Description

General description

5,6-dimethylxanthenone-4-acetic acid (DMXAA) is a flavone acetic acid derivative. It acts as a vascular disrupting agent (VDA), which damages tumor vasculature and stimulates an anti-tumor immune response. It stimulates hemorrhagic necrosis.

Application

5,6-dimethylxanthenone-4-acetic acid (DMXAA) has been used to induce type-I IFN signaling in a stimulator of interferon genes (STING) dependent manner. It has also been used to study STING-dependent signaling in the absence of infection.

Biochem/physiol Actions

DMXAA is an apoptosis inducer; anti-vascular.

Features and Benefits

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Safety Information

• Pictograms: GHS07,GHS09
• Signal Word: Warning
• Hazard Statements: H302,H400
• Precautionary Statements: P273 - P301 + P312 + P330
• Hazard Classifications: Acute Tox. 4 Oral - Aquatic Acute 1
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves