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764604

Sigma-Aldrich

Polyethylenimine, linear

average Mn 2100, PDI <1.3

Synonym(s):

PEI

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About This Item

Linear Formula:
(CH2CH2NH)n
CAS Number:
9002-98-6
UNSPSC Code:
12162002
NACRES:
NA.23

form

liquid

mol wt

average Mn 2100

mp

59-64 °C

transition temp

Tm 59-64 °C

PDI

<1.3

storage temp.

2-8°C

InChI

1S/C2H5N/c1-2-3-1/h3H,1-2H2

InChI key

NOWKCMXCCJGMRR-UHFFFAOYSA-N

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General description

Polyethylenimine(PEI) is a synthetic cationic polymerwith high charge density and chain flexibility. It is the most widelyinvestigated cationic polymer for non-viral delivery of nucleic acids. LinearPEI can be an effective carrier for a wide range of gene medicine including DNAplasmids, small interfering RNAs, and mRNAs. It protects the DNA from theacidic environment and ensures the release of DNA to the cytoplasm.

Application

  • Water-soluble linear poly (ethylenimine) as a superior bifunctional binder for lithium–sulfur batteries: Demonstrates the utility of water-soluble linear polyethylenimine as an effective bifunctional binder that enhances the cycle stability and efficiency of lithium-sulfur batteries, pivotal for advancing battery technology (Liao et al., 2018).

Signal Word

Danger

Hazard Statements

H302,H317,H318,H411

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Dam. 1 - Skin Sens. 1

Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

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Lei Feng et al.
Engineering in life sciences, 20(8), 320-330 (2020-08-11)
As the main immunogen that could stimulate neutralized antibody in pigs, recombinant E2 protein of CSFV was expressed in CHO-dhfr-cells driven by endogenous Txnip promoter from Chinese hamster. Different fragments of Txnip promoter were amplified by PCR from isolated genomic
Laura R H Ip et al.
Oncotarget, 6(12), 10548-10562 (2015-04-15)
Treatment options for ovarian cancer patients remain limited and overall survival is less than 50% despite recent clinical advances. The lipid phosphatase inositol polyphosphate 4-phosphatase type II (INPP4B) has been described as a tumor suppressor in the PI3K/Akt pathway with

Articles

Delivery of Nucleic Acids Using Polymers

This review will focus on the sub-sector of drug delivery concerning the delivery of nucleic acids, with a particular focus on poly(ethyleneimine).

Functionalized PEI and Its Role in Gene Therapy

Gene therapy has become one of the most discussed techniques in biomedical research in recent years.

Nanoparticle-Based Drug and Gene Delivery for Tumor Targeting

Professor Yoshiki Katayama (Kyushu University, Japan) discusses recent advances in drug delivery systems and strategies that exploit the EPR effect, with a special focus on stimuli-responsive systems based on novel materials.

Progress on Nonviral Delivery for CRISPR/Cas9

CRISPR/Cas9 delivery via nonviral nanoparticles shows promising advancements for gene editing in disease treatment.

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