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Phosphine-catalyzed annulation of thioamides and 2-alkynoates: a new synthesis of thiazolines.

The Journal of organic chemistry (2002-06-22)
Bing Liu, Roman Davis, Biren Joshi, Daniel W Reynolds
RESUMEN

The annulation of thioamides with 2-alkynoates and 2,3-dienoates under the catalysis of tri-n-butylphosphine was described. The annulation reaction provided a new entry to thiazolines, particularly those with 2-aryl substituents.

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Sigma-Aldrich
Ethyl 2-butynoate, 98%