Saltar al contenido
Merck

The adverse effects of mild-to-moderate iodine deficiency during pregnancy and childhood: a review.

Thyroid : official journal of the American Thyroid Association (2007-10-25)
Michael B Zimmermann
RESUMEN

Iodine is required for the production of thyroid hormones, which are essential for normal brain development, and the fetus, newborn, and young child are particularly vulnerable to iodine deficiency. The iodine requirement increases during pregnancy and recommended intakes are in the range of 220-250 microg/day. Monitoring iodine status during pregnancy is a challenge. New recommendations from World Health Organization suggest that a median urinary iodine concentration >250 microg/L and <500 microg/L indicates adequate iodine intake in pregnancy. Based on this range, it appears that many pregnant women in Western Europe have inadequate intakes. A recent Swiss study has suggested that thyroid-stimulating hormone concentration in the newborn is a sensitive indicator of mild iodine deficiency in late pregnancy. The potential adverse effects of mild iodine deficiency during pregnancy are uncertain. Controlled trials of iodine supplementation in mildly iodine-deficient pregnant women suggest beneficial effects on maternal and newborn serum thyroglobulin and thyroid volume, but no effects on maternal and newborn total or free thyroid hormone concentrations. There are no long-term data on the effect of iodine supplementation on birth outcomes or infant development. New data from well-controlled studies indicate that iodine repletion in moderately iodine-deficient school-age children has clear benefits: it improves cognitive and motor function; it also increases concentrations of insulin-like growth factor 1 and insulin-like growth factor-binding protein 3, and improves somatic growth.

MATERIALES
Referencia del producto
Marca
Descripción del producto

Sigma-Aldrich
Yodo, ACS reagent, ≥99.8%, solid
Número de referencia del producto (SKU)
Tamaño de envase
Disponibilidad
Precio
Cantidad
Sigma-Aldrich
Yodo, flakes, ReagentPlus®, ≥99%
Número de referencia del producto (SKU)
Tamaño de envase
Disponibilidad
Precio
Cantidad
Supelco
Yodo, ReagentPlus®, ≥99.8% (titration)
Número de referencia del producto (SKU)
Tamaño de envase
Disponibilidad
Precio
Cantidad
Sigma-Aldrich
Yodo, ≥99.99% trace metals basis
Número de referencia del producto (SKU)
Tamaño de envase
Disponibilidad
Precio
Cantidad
Sigma-Aldrich
Yodo, puriss., meets analytical specification of Ph. Eur., BP, USP, 99.8-100.5%
Número de referencia del producto (SKU)
Tamaño de envase
Disponibilidad
Precio
Cantidad
Sigma-Aldrich
Yodo, ReagentPlus®, 99.7% trace metals basis, beads, 1-3 mm
Número de referencia del producto (SKU)
Tamaño de envase
Disponibilidad
Precio
Cantidad
Sigma-Aldrich
Yodo, 99.999% trace metals basis
Número de referencia del producto (SKU)
Tamaño de envase
Disponibilidad
Precio
Cantidad
Sigma-Aldrich
Yodo, anhydrous, beads, −10 mesh, 99.999% trace metals basis
Número de referencia del producto (SKU)
Tamaño de envase
Disponibilidad
Precio
Cantidad
Sigma-Aldrich
Yodo, puriss., ≥99.5% (RT), particles (round)
Número de referencia del producto (SKU)
Tamaño de envase
Disponibilidad
Precio
Cantidad