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Dose proportionality study of loperamide following oral administration of loperamide oxide.

European journal of clinical pharmacology (1992-01-01)
F Kamali, L Adriaens, M L Huang, R Woestenborghs, M Emanuel, M D Rawlins
RESUMEN

The pharmacokinetics of loperamide, after oral administration of increasing doses (1 to 16 mg) of loperamide oxide, has been investigated in 10 healthy male volunteers, using a randomised cross-over design. Comparison of the maximum plasma loperamide concentration and AUC demonstrated that the bioavailability of loperamide was proportional to the dose of loperamide oxide administered.

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Loperamide oxide monohydrate, European Pharmacopoeia (EP) Reference Standard