- Assessing the degradation profile of functional aliphatic polyesters with precise control of the degradation products.
Assessing the degradation profile of functional aliphatic polyesters with precise control of the degradation products.
Macromolecular bioscience (2011-11-19)
Anders Höglund, Sofia Målberg, Ann-Christine Albertsson
PMID22095708
RESUMEN
The pre-polymer poly(but-2-ene-1,4-diyl malonate) (PBM) and a series of PBM-based materials are shown to be degradable under physiological conditions in vitro and they are therefore presented as potential materials for biomedical applications. Four different PBM-based materials are synthesized: a PBM homopolymer, crosslinked PBM with and without spacer, and a triblock copolymer of PBM and PLLA with the PBM as an amorphous middle block. The polymers are subjected to hydrolytic degradation in phosphate-buffered saline at pH = 7.4 and 37 °C. The results show that all the PBM-based materials degrade without a rapid release of acidic degradation products or any substantial lowering of the pH that might jeopardize their biocompatibility.