- Highly regioselective Au(I)-catalyzed hydroamination of ynamides and propiolic acid derivatives with anilines.
Highly regioselective Au(I)-catalyzed hydroamination of ynamides and propiolic acid derivatives with anilines.
Organic letters (2009-08-25)
Søren Kramer, Karin Dooleweerdt, Anders Thyboe Lindhardt, Mario Rottländer, Troels Skrydstrup
PMID19697920
RESUMEN
A highly regioselective hydroamination of unsymmetrical electron-poor and electron-rich alkynes with anilines catalyzed by Au(I) under mild conditions is reported. In addition, applications toward indole syntheses are presented including an example of a one-pot synthesis from a nonfunctionalized aniline.
MATERIALES