- Anti-malarial activity of Baylis-Hillman adducts from substituted 2-chloronicotinaldehydes.
Anti-malarial activity of Baylis-Hillman adducts from substituted 2-chloronicotinaldehydes.
Bioorganic & medicinal chemistry letters (2005-10-11)
P Narender, U Srinivas, B Gangadasu, Sukla Biswas, V Jayathirtha Rao
PMID16213708
RESUMEN
New Baylis-Hillman adducts are synthesized based on substituted 2-chloronicotinaldehydes and screened for their in vitro anti-malarial activity against chloroquine sensitive and chloroquine resistant Plasmodium falciparum. Out of the six new compounds synthesized and screened, 2b, 2c and 2d compounds showed substantial anti-malarial activity.
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