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Merck

Mild Pd-catalyzed aminocarbonylation of (hetero)aryl bromides with a palladacycle precatalyst.

Organic letters (2014-08-05)
Stig D Friis, Troels Skrydstrup, Stephen L Buchwald
RESUMEN

A palladacyclic precatalyst is employed to cleanly generate a highly active XantPhos-ligated Pd-catalyst. Its use in low temperature aminocarbonylations of (hetero)aryl bromides provides access to a range of challenging products in good to excellent yields with low catalyst loading and only a slight excess of CO. Some products are unattainable by traditional carbonylative coupling.

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Sigma-Aldrich
DPPF Pd G4 ChemBeads