R3905

Ro273225 trifluoroacetate salt

≥98% (reversed phase HPLC)

• Sinónimos: Butir-His-D-Phe-Arg-Trp-Sar-NH2 trifluoroacetate salt
• Fórmula empírica (notación de Hill): C₃₉H₅₂N₁₂O₆ · xC₂HF₃O₂
• Número de CAS: 1057258-86-2
• Peso molecular: 784.91 (free base basis)
• MDL number: MFCD04112656
• UNSPSC Code: 51111800
• PubChem Substance ID: 329824026
• NACRES: NA.77

Propiedades

• Quality Level: 100
• assay: ≥98% (reversed phase HPLC)
• form: lyophilized solid
• color: white
• solubility: H₂O: >10 mg/mL
• storage temp.: room temp
• SMILES string: CCCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N(C)CC(N)=O
• InChI: 1S/C39H52N12O6/c1-3-10-34(53)47-31(19-26-21-43-23-46-26)37(56)49-30(17-24-11-5-4-6-12-24)36(55)48-29(15-9-16-44-39(41)42)35(54)50-32(38(57)51(2)22-33(40)52)18-25-20-45-28-14-8-7-13-27(25)28/h4-8,11-14,20-21,23,29-32,45H,3,9-10,15-19,22H2,1-2H3,(H2,40,52)(H,43,46)(H,47,53)(H,48,55)(H,49,56)(H,50,54)(H4,41,42,44)/t29-,30-,31-,32-/m0/s1
• InChI key: NINOPZAAGJJNAR-YDPTYEFTSA-N

Descripción

Amino Acid Sequence

Butir-His-Phe-Arg-Trp-Sar-NH2

Biochem/physiol Actions

Ro 27-3225 is a selective melanocortin MC4 receptor agonist. EC50 = 1 nM. Ro 27-3225 shows some activity at the MC1 receptor. Ro 27-3225 reverses hemorrhagic shock, reduces multiple organ damage, and improves survival. Ro 27-3225 may have a protective role against multiple organ failure following circulatory shock. Ro 27-3225 also reduces food intake in ob/ob mice.

Features and Benefits

This compound is featured on the Melanocortin Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Información de seguridad

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)