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  • 2-Butoxyethanol model of haemolysis and disseminated thrombosis in female rats: a preliminary study of the vascular mechanism of osteoarthritis in the temporomandibular joint.

2-Butoxyethanol model of haemolysis and disseminated thrombosis in female rats: a preliminary study of the vascular mechanism of osteoarthritis in the temporomandibular joint.

The British journal of oral & maxillofacial surgery (2009-12-26)
G Amir, A W Goldfarb, M Nyska, M Redlich, A Nyska, D W Nitzan
ABSTRACT

Female rats develop haemolytic anaemia and disseminated thrombosis and infarction in multiple organs, including bone, when exposed to 2-butoxyethanol (BE). There is growing evidence that vascular occlusion of the subchondral bone may play a part in some cases of osteoarthritis. The subchondral bone is the main weight bearer as well as the source of the blood supply to the mandibular articular cartilage. Vascular occlusion is thought to be linked to sclerosis of the subchondral bone associated with disintegration of the articular cartilage. The aim of this study was to find out whether this model of haemolysis and disseminated thrombosis supports the vascular hypothesis of osteoarthritis. Six female rats were given BE orally for 4 consecutive days and the two control rats were given tap water alone. The rats were killed 26 days after the final dose. The mandibular condyles showed histological and radiological features consistent with osteoarthritis in three of the four experimental rats and in neither of the control rats. These results may support the need to explore the vascular mechanism of osteoarthritis further.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Ethylene glycol butyl ether, SAJ first grade, ≥99.0%
Supelco
Ethylene glycol butyl ether, analytical standard
Sigma-Aldrich
Ethylene glycol butyl ether, ≥99%
Sigma-Aldrich
Ethylene glycol butyl ether, spectrophotometric grade, ≥99.0%