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Merck

Lactone-free ginkgolides via regioselective DIBAL-H reduction.

Organic & biomolecular chemistry (2005-09-21)
Hideki Ishii, Sergei V Dzyuba, Koji Nakanishi
ABSTRACT

The lactone rings of ginkgolide A are converted into corresponding tetrahydrofuran moieties via DIBAL-H reduction followed by deoxygenation of the formed lactols with Et3SiH-BF3.Et2O to produce a series of lactone-free ginkgolides.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Diisobutylaluminum hydride solution, 1.0 M in methylene chloride
Sigma-Aldrich
Diisobutylaluminum hydride solution, 1.0 M in toluene
Sigma-Aldrich
Diisobutylaluminum hydride solution, 1.0 M in THF
Sigma-Aldrich
Diisobutylaluminum hydride solution, 1.0 M in cyclohexane
Sigma-Aldrich
Diisobutylaluminum hydride, reagent grade
Sigma-Aldrich
Diisobutylaluminum hydride solution, 1.0 M in hexanes
Sigma-Aldrich
Diisobutylaluminum hydride solution, 25 wt. % in toluene
Sigma-Aldrich
Diisobutylaluminum hydride solution, 1.0 M in heptane