SBR00065

Rifampicin Ready Made Solution

50 mg/mL in DMSO

• Empirical Formula (Hill Notation): C₄₃H₅₈N₄O₁₂
• CAS Number: 13292-46-1
• Molecular Weight: 822.94
• UNSPSC Code: 41116107
• NACRES: NA.76

Properties

• form: liquid
• Quality Level: 200
• specific activity: Antibacterial
• concentration: 50 mg/mL in DMSO
• antibiotic activity spectrum: Gram-negative bacteria; Gram-positive bacteria; mycobacteria; viruses
• Mode of action: protein synthesis | interferes
• storage temp.: −20°C
• InChI: 1S/C43H58N4O12/c1-21-12-11-13-22(2)42(55)45-33-28(20-44-47-17-15-46(9)16-18-47)37(52)30-31(38(33)53)36(51)26(6)40-32(30)41(54)43(8,59-40)57-19-14-29(56-10)23(3)39(58-27(7)48)25(5)35(50)24(4)34(21)49/h11-14,19-21,23-25,29,34-35,39,49-53H,15-18H2,1-10H3,(H,45,55)/b12-11+,19-14+,22-13-,44-20+/t21-,23+,24+,25+,29-,34-,35+,39+,43-/m0/s1
• InChI key: JQXXHWHPUNPDRT-WLSIYKJHSA-N

Description

General description

Rifampicin is a microlide antibiotic effective against gram-positive and gram-negative bacteria, mycobacteria and viruses.

Application

• Rifampicin is used to treat Tuberculosis and Tuberculosis-related mycobacterial infections.
• Rifampicin is widely used as an antipruritic agent in the autoimmune cholestatic liver disease, and primary biliary cirrhosis (PBC).
• Rifampicin was also found active by inhibiting Tau Oligomer Propagation in Alzheimer’s disease.
• Rifampicin is used as a selection agent for agrobacterium mediated plant transformation.

Biochem/physiol Actions

Inhibits the assembly of DNA and protein into mature virus particles.

Mode of Action: Inhibits initiation of RNA synthesis by binding to β-subunit of RNA polymerase.

Other Notes

The product is supplied in DMSO at a concentration of 50 mg/mL. Working concentrations for agrobacterium selection are typically 10-50 mg/L.

Safety Information

• Hazard Statements: H362
• Precautionary Statements: P201 - P202 - P263 - P264 - P270 - P308 + P313
• Hazard Classifications: Lact.
• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 1
• Flash Point(F): 188.6 °F - closed cup
• Flash Point(C): 87 °C - closed cup