Pharmacology & Drug Discovery Research

Phase I Drug Metabolism
Phase I biotransformation reactions increase drug compound polarity, mainly occurring in hepatic circulation.
Inhibition of Nucleic Acid Synthesis by Antibiotics
Explore how antibiotics, particularly quinolones, inhibit nucleic acid synthesis by targeting topoisomerases, crucial for DNA replication processes.
3D Cell Culture Tools and Techniques
3D cell culture overview. Learn about 2D vs 3D cell culture, advantages of 3D cell culture, and techniques available to develop 3D cell models
The Role of Intestinal Efflux Transporters In Drug Absorption
We presents an article on The Role of Intestinal Efflux Transporters In Drug Absorption.
Chromatography Profile Analysis of Phosphorothioate Oligonucleotides
The ultimate goal of most antisense research is to develop therapeutic agents for diseases such as diabetes, cancer, and HIV/ AIDS. Phosphorothioate oligonucleotides (commonly referred to as S-oligos) are often the molecules of choice because of their resistance to cellular nuclease degradation.
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Related Protocols

Liposome Preparation - Avanti® Polar Lipids
Lipid vesicle preparation involves hydration and sizing steps, applicable regardless of lipid composition.
General Lipid/BSA Solubilization Protocol For Cell Delivery
General Lipid/BSA solubility protocol for cell delivery. Organic solvent suspended method for the preparation of lipid stock solutions.
HDM-PAMPA with the MultiScreen Permeability Filter Plate
Assays that predict passive absorption of orally administered drugs have become increasingly important in the drug discovery process. As previously described by Faller and Kansy such assays provide rapid, low cost and automation friendly methods to measure a compound’s passive permeability.
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