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Merck
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Key Documents

L0636

Sigma-Aldrich

Lectin from Triticum vulgaris (wheat)

suitable for cell culture, BioReagent, lyophilized powder

Sinónimos:

WGA, Wheat germ agglutinin

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About This Item

UNSPSC Code:
12352202
NACRES:
NA.32

sterility

aseptically processed

Quality Level

200

product line

BioReagent

form

lyophilized powder

technique(s)

cell culture | mammalian: suitable

impurities

salt, essentially free

storage temp.

2-8°C

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General description

Lectin from Triticum vulgaris (wheat) is a dimeric glycoprotein of 36 kDa. It belongs to the family of chitin-binding proteins. Glycosylated precursor of lectin is synthesized in endoplasmic reticulum.

Application

Lectin from Triticum vulgaris (wheat) has been used:
  • to conjugate with N-hydroxysuccinimide (NHS) dye
  • to inhibit nuclear import
  • to inhibit the nuclear pore of human cervical carcinoma HeLa and SiHa cells

Biochem/physiol Actions

Lectin from Triticum vulgaris (wheat) possessing four binding sites is specific for N-acetyl-d-glucosamine and N-acetyl-d-neuraminic acid (sialic acid) residues. Lectins also function as a fungicide. They also possess anti-nutritive effects.
WGA is not blood group specific but has an affinity for N-acetyl-β-D-glucosaminyl residues and N-acetyl-β-D-glucosamine oligomers. WGA contains no protein-bound carbohydrate.

Other Notes

Highly purified

Preparation Note

Conjugates are prepared from affinity purified lectin.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Plant lectins: occurrence, biochemistry, functions and applications
Rudiger H and Gabius HJ
Glycoconjugate Journal, 18, 589-613 (2001)
Effects of wheat germ agglutinin on human gastrointestinal epithelium: insights from an experimental model of immune/epithelial cell interaction
Dalla P, et al.
Toxicology and Applied Pharmacology, 237, 146-153 (2009)
Super-multiplex vibrational imaging
Wei L, et al.
Nature, 544, 465-465 (2017)
Tsung-Lin Tsai et al.
International journal of nanomedicine, 7, 5215-5234 (2012-10-17)
Gold nanoparticles modified with the nuclear localization signal from simian virus 40 large T antigen (GNP-PEG/SV40) accumulate on the cytoplasmic side of the nuclear membrane in HeLa cells. Accumulation of GNP-PEG/SV40 around the nucleus blocks nucleocytoplasmic transport and prevents RNA
Pengfei Zhang et al.
Chemical science, 13(43), 12760-12768 (2022-12-16)
Exosome analysis is a promising tool for clinical and biological research applications. However, detection and biomarker quantification of exosomes is technically challenging because they are small and highly heterogeneous. Here, we report an optical approach for imaging exosomes and quantifying
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Find the right lectin for your research with our lectin selection guide, organized by lectin source/species, carbohydrate specificity, blood group specificity, and more.

Lectin Selection Guide: A Useful Guide for Selecting the Right Lectin

Find the right lectin for your research with our lectin selection guide, organized by lectin source/species, carbohydrate specificity, blood group specificity, and more.

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