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Key Documents

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A0788

Sigma-Aldrich

3-Aminobenzamide

≥99% (TLC)

Sinónimos:

3-AB, 3-ABA

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About This Item

Fórmula lineal:
H2NC6H4CONH2
Número de CAS:
3544-24-9
Peso molecular:
136.15
EC Number:
222-586-9
MDL number:
MFCD00007989
UNSPSC Code:
12352200
PubChem Substance ID:
24278206
NACRES:
NA.77

assay

≥99% (TLC)

form

powder

color

white to off-white

mp

115-116 °C (lit.)

solubility

ethanol: 50 mg/mL, clear, light yellow
DMSO: soluble
H2O: soluble (may require gentle heating)

storage temp.

room temp

SMILES string

NC(=O)c1cccc(N)c1

InChI

1S/C7H8N2O/c8-6-3-1-2-5(4-6)7(9)10/h1-4H,8H2,(H2,9,10)

Inchi Key

GSCPDZHWVNUUFI-UHFFFAOYSA-N

Gene Information

mouse ... Parp1(11545)

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Application

3-Aminobenzamide has been used as a poly-(ADP-ribose) polymerase (PARP) inhibitor in various experimental studies.

Biochem/physiol Actions

3-Aminobenzamide enhances cell death, unscheduled DNA synthesis and repair replication by interrupting the rejoining of DNA strand breaks induced by both ionizing radiations and several alkylating agents. It has an ability to inhibit the activity of nuclear enzyme poly (ADP-ribose) synthetase (PARS). 3-Aminobenzamide exhibits protective action against myocardial reperfusion injury and local inflammation.

Features and Benefits

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

ppe

dust mask type N95 (US), Eyeshields, Gloves

Certificados de análisis (COA)

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Poly (ADP-ribose) synthetase inhibition prevents lipopolysaccharide-induced peroxynitrite mediated damage in diaphragm
OzduLger A, et al.
Pharmacological Research, 46(1), 67-73 (2002)
Protection against myocardial ischemia and reperfusion injury by 3-aminobenzamide, an inhibitor of poly (ADP-ribose) synthetase
Zingarelli B, et al.
Cardiovascular Research, 36(2), 205-215 (1997)
Feyza Ademoğlu et al.
Pharmacology, 66(1), 1-4 (2002-08-10)
We have previously reported that peroxynitrite (ONOO(-)) caused relaxations on isolated rat anococcygeus muscle and in the present study the possible mechanisms of the relaxant effect were investigated. ONOO(-) (0.03- 1.0 mmol/l)-induced relaxations were reduced significantly by the presence of
Effect of 3-aminobenzamide on the rate of ligation during repair of alkylated DNA in human fibroblasts
Morgan W and Cleaver J
Cancer Research, 43(7), 3104-3107 (1983)
Protective effects of 3-aminobenzamide, an inhibitor of poly (ADP-ribose) synthase in a carrageenan-induced model of local inflammation
Cuzzocrea S, et al.
European Journal of Pharmacology, 342(1), 67-76 (1998)
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