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123129

Sigma-Aldrich

2-Aminothiazole

97%

Sinónimos:

2-Thiazolamine

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About This Item

Fórmula empírica (notación de Hill):
C3H4N2S
Número de CAS:
96-50-4
Peso molecular:
100.14
Beilstein/REAXYS Number:
105738
EC Number:
202-511-6
MDL number:
MFCD00005325
UNSPSC Code:
12352100
PubChem Substance ID:
24847523
NACRES:
NA.22

assay

97%

mp

91-93 °C (lit.)

solubility

1 M HCl: soluble 50 mg/mL, clear (dark yellow-brown)

SMILES string

Nc1nccs1

InChI

1S/C3H4N2S/c4-3-5-1-2-6-3/h1-2H,(H2,4,5)

InChI key

RAIPHJJURHTUIC-UHFFFAOYSA-N

Application

2-Aminothiazole was used in the synthesis of 2-aminothiazole-modified silica gel. It was used in Ulmann coupling with 2-chlorobenzoic acids mediated by ultrasonic irradiation.

Biochem/physiol Actions

2-Aminothiazoles are potent cyclin-dependent kinase 5 inhibitors and are therapeutic agents for the treatment of Alzheimer′s disease and other neurodegenerative disorders.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Certificados de análisis (COA)

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Christopher J Helal et al.
Bioorganic & medicinal chemistry letters, 14(22), 5521-5525 (2004-10-16)
High-throughput screening with cyclin-dependent kinase 5 (cdk5)/p25 led to the discovery of N-(5-isopropyl-thiazol-2-yl)isobutyramide (1). This compound is an equipotent inhibitor of cdk5 and cyclin-dependent kinase 2 (cdk2)/cyclin E (IC(50)=ca. 320nM). Parallel and directed synthesis techniques were utilized to explore the
Xin Cao et al.
Bioorganic & medicinal chemistry, 16(11), 5890-5898 (2008-05-20)
Because both c-Src and iNOS are key regulatory enzymes in tumorigenesis, a new series of 4-heteroarylamino-3-quinolinecarbonitriles as potent dual inhibitors of both enzymes were designed, prepared, and evaluated for blocking multiple signaling pathways in cancer therapy. All compounds were evaluated
P S Roldan et al.
Analytical and bioanalytical chemistry, 375(4), 574-577 (2003-03-01)
This work describes the synthesis and characterization of 2-aminothiazole-modified silica gel (SiAT), as well as its application for preconcentration (in batch and column technique) of Cu(II), Ni(II) and Zn(II) in ethanol medium. The adsorption capacities of SiAT determined for each
Synthetic Communications, 37, 1853-1853 (2007)
Sina Ghaemmaghami et al.
Journal of virology, 84(7), 3408-3412 (2009-12-25)
Prion diseases are fatal, untreatable neurodegenerative diseases caused by the accumulation of the misfolded, infectious isoform of the prion protein (PrP), termed PrP(Sc). In an effort to identify novel inhibitors of prion formation, we utilized a high-throughput enzyme-linked immunosorbent assay
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