R3250

Retinyl acetate

synthetic, matrix dispersion, 475,000-650,000 USP units/g

• Synonym(s): Retinol acetate, Vitamin A acetate
• Empirical Formula (Hill Notation): C₂₂H₃₂O₂
• CAS Number: 127-47-9
• Molecular Weight: 328.49
• Beilstein: 1915439
• EC Number: 204-844-2
• MDL number: MFCD00019413
• UNSPSC Code: 12352205
• eCl@ss: 34058009
• PubChem Substance ID: 57654589
• NACRES: NA.79

Properties

• biological source: synthetic
• form: matrix dispersion
• specific activity: 475,000-650,000 USP units/g
• color: yellow
• mp: 57-58 °C
• storage temp.: −20°C
• SMILES string: CC1=C(/C=C/C(C)=C/C=C/C(C)=C/COC(C)=O)C(C)(C)CCC1
• InChI: 1S/C22H32O2/c1-17(9-7-10-18(2)14-16-24-20(4)23)12-13-21-19(3)11-8-15-22(21,5)6/h7,9-10,12-14H,8,11,15-16H2,1-6H3/b10-7+,13-12+,17-9+,18-14+
• InChI key: QGNJRVVDBSJHIZ-QHLGVNSISA-N

Description

General description

Retinal, retinol and retinoic acid are the aldehyde, alcohol and acid forms of vitamin A. The retinoids exist as many geometric isomers due to the unsaturated bonds in the aliphatic chain. Retinoids also exist as retinyl esters such as retinyl propionate, retinyl acetate and retinyl palmitate.

Application

Retinyl acetate has been used:

• a control diet to study its effect at different developmental periods in fish larvae
• to study its inhibitory effects on Mycobacterium avium subspecies paratuberculosis (MAP) strains
• as an internal standard in high performance liquid chromatography (HPLC) to quantify vitamin A in fortified milk

Biochem/physiol Actions

Retinyl esters provide pools of vitamin A that are converted into retinol and other retinoids as required. Retinyl acetate is used in a wide range of biological applications. It acts as a chemopreventive agent. Retinyl acetate also has antineoplastic property.

Physical form

Dispersion in cornstarch-gelatin matrix. Oil dispersible

Analysis Note

Activity based on HPLC comparison to USP standard.

Safety Information

• Pictograms: GHS08
• Signal Word: Danger
• Hazard Statements: H360D,H413
• Precautionary Statements: P202 - P273 - P280 - P308 + P313 - P405 - P501
• Hazard Classifications: Aquatic Chronic 4 - Repr. 1B
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 2
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves