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Key Documents

P4154

Sigma-Aldrich

Polyinosinic acid potassium salt

Homopolymer

Synonym(s):

Poly(I) potassium salt

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About This Item

CAS Number:
26936-41-4
MDL number:
MFCD00131982
UNSPSC Code:
41106305
NACRES:
NA.51

biological source

synthetic (organic)

Quality Level

200

Assay

≥98% (TLC)

form

lyophilized powder

solubility

water: 4.80-5.20 mg/mL, clear to hazy, colorless to faintly yellow

storage temp.

−20°C

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Application

Polyinosinic acid (Poly(I)) is a homopolymer of inosine that may be used with polycytidylic acid (poly(C)) to form the double-stranded homopolymer (Poly(I) • Poly(C)). TLR3 recognizes double-stranded RNA and is a major effector of the immune response against viral pathogens. (Poly(I) • Poly(C)) is a used as a model RNA to study cell signaling at the level of TLR3. Poly(IC) is a TRIF-dependent toll-like receptor-3 (TLR3) ligand.

Preparation Note

Prepared from IDP using polynucleotide phosphorylase.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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