▾Xiapex for Dupuytren's contracture.

▾Xiapex for Dupuytren's contracture.

Drug and therapeutics bulletin (2011-12-16)

RÉSUMÉ

Dupuytren's contracture is a benign, progressive disabling condition of the hands. Traditionally, surgery (e.g. fasciotomy, fasciectomy, joint fusion and amputation) has been the only effective treatment but it is not an option for every patient. A potential alternative intervention is a formulation of collagenase Clostridium histolyticum (▾Xiapex--Pfizer Limited), which has been licensed for injection directly into the affected joint as treatment for adults with Dupuytren's contracture.5 Here we review the evidence for collagenase C. histolyticum and discuss its place in the management of this condition.

MATÉRIAUX

Référence du produit

Marque

Description du produit

C5138

Sigma-Aldrich

Collagénase from Clostridium histolyticum, suitable for release of physiologically active rat hepatocytes, Type IV, 0.5-5.0 FALGPA units/mg solid, ≥125 CDU/mg solid

C0130

Sigma-Aldrich

Collagénase from Clostridium histolyticum, for general use, Type I, ≥125 CDU/mg solid

C6885

Sigma-Aldrich

Collagénase from Clostridium histolyticum, suitable for release of physiologically active rat epididymal adipocytes, Type II, 0.5-5.0 FALGPA units/mg solid, ≥125 CDU/mg solid

C9891

Sigma-Aldrich

Collagénase from Clostridium histolyticum, Type IA, 0.5-5.0 FALGPA units/mg solid, ≥125 CDU/mg solid, For general use

C2139

Sigma-Aldrich

Collagénase from Clostridium histolyticum, suitable for release of rat epididymal adipocytes and hepatocytes (for methodology see Type II and Type IV), Type VIII, 0.5-5.0 FALGPA units/mg solid, ≥125 CDU/mg solid

C7657

Sigma-Aldrich

Collagénase from Clostridium histolyticum, Type XI, 2-5 FALGPA units/mg solid, ≥800 CDU/mg solid

C9263

Sigma-Aldrich

Collagénase from Clostridium histolyticum, Type V, ≥1 FALGPA units/mg solid, >125 CDU/mg solid

C9407

Sigma-Aldrich

Collagénase from Clostridium histolyticum, powder, Suitable for the digestion and isolation of physiologically active pancreatic islet cells, suitable for cell culture

C2674

Sigma-Aldrich

Collagénase from Clostridium histolyticum, lyophilized powder, ≥125 CDU/mg solid (CDU = collagen digestion units), 0.5-5.0 FALGPA units/mg solid

C2399

Sigma-Aldrich

Collagénase from Clostridium histolyticum, 0.2 μm filtered, high purity, purified by chromatography, Type VII-S, ≥4 FALGPA units/mg solid, ≥700 CDU/mg solid (CDU = collagen digestion units)

C9722

Sigma-Aldrich

Collagénase from Clostridium histolyticum, lyophilized powder (from 0.2μm filtered solution), 0.5-5.0 FALGPA units/mg solid, suitable for cell culture

C1889

Sigma-Aldrich

Collagénase from Clostridium histolyticum, 0.2 μm filtered, suitable for release of physiologically active rat hepatocytes, Type IV-S, 0.5-5.0 FALGPA units/mg solid, ≥125 CDU/mg solid

C0773

Sigma-Aldrich

Collagénase from Clostridium histolyticum, high purity, purified by chromatography, Type VII, ≥4 FALGPA units/mg solid, lyophilized powder, ≥700 CDU/mg solid (CDU = collagen digestion units)

C9697

Sigma-Aldrich

Collagénase from Clostridium histolyticum, lyophilized powder (from 0.2 μm filtered solution), suitable for cell culture

C1639

Sigma-Aldrich

Collagénase from Clostridium histolyticum, 0.2 μm filtered, for general use, Type I-S, 0.2-1.0 FALGPA units/mg solid, ≥125 CDU/mg solid

C2799

Sigma-Aldrich

Collagénase from Clostridium histolyticum, powder, suitable for cell culture, ≥4 FALGPA units/mg solid, high purity, ≥700 CDU/mg solid (CDU = collagen digestion units)

C1764

Sigma-Aldrich

Collagénase from Clostridium histolyticum, 0.2 μm filtered, suitable for release of physiologically active rat epididymal adipocytes, Type II-S, 0.5-5.0 FALGPA units/mg solid, ≥125 CDU/mg solid

C8051

Sigma-Aldrich

Collagénase from Clostridium histolyticum, Sigma Blend Type H, ≥1.0 FALGPA units/mg solid

C5894

Sigma-Aldrich

Collagénase from Clostridium histolyticum, non-sterile; 0.2 μm filtered, Type IA-S, 0.5-5.0 FALGPA units/mg solid, ≥125 CDU/mg solid

C7926

Sigma-Aldrich

Collagénase from Clostridium histolyticum, Sigma Blend Type F, ≥2.0 FALGPA units/mg solid

C0255

Sigma-Aldrich

Collagénase from Clostridium histolyticum, purified by chromatography, ≥500 CDU/mg solid (CDU = collagen digestion units), lyophilized powder

C2014

Sigma-Aldrich

Collagénase from Clostridium histolyticum, 0.2 μm filtered, Type V-S, ≥1 FALGPA units/mg solid, ≥125 CDU/mg solid

C8176

Sigma-Aldrich

Collagénase from Clostridium histolyticum, Sigma Blend Type L, ≤1.0 FALGPA units/mg solid