Genome-wide association studies identify IL23R-IL12RB2 and IL10 as Behçet's disease susceptibility loci.

Genome-wide association studies identify IL23R-IL12RB2 and IL10 as Behçet's disease susceptibility loci.

Nature genetics (2010-07-14)

Nobuhisa Mizuki, Akira Meguro, Masao Ota, Shigeaki Ohno, Tomoko Shiota, Tatsukata Kawagoe, Norihiko Ito, Jiro Kera, Eiichi Okada, Keisuke Yatsu, Yeong-Wook Song, Eun-Bong Lee, Nobuyoshi Kitaichi, Kenichi Namba, Yukihiro Horie, Mitsuhiro Takeno, Sunao Sugita, Manabu Mochizuki, Seiamak Bahram, Yoshiaki Ishigatsubo, Hidetoshi Inoko

PMID20622879

RÉSUMÉ

Behçet's disease is a chronic systemic inflammatory disorder characterized by four major manifestations: recurrent ocular symptoms, oral and genital ulcers and skin lesions. We conducted a genome-wide association study in a Japanese cohort including 612 individuals with Behçet's disease and 740 unaffected individuals (controls). We identified two suggestive associations on chromosomes 1p31.3 (IL23R-IL12RB2, rs12119179, P = 2.7 x 10(-8)) and 1q32.1 (IL10, rs1554286, P = 8.0 x 10(-8)). A meta-analysis of these two loci with results from additional Turkish and Korean cohorts showed genome-wide significant associations (rs1495965 in IL23R-IL12RB2, P = 1.9 x 10(-11), odds ratio = 1.35; rs1800871 in IL10, P = 1.0 x 10(-14), odds ratio = 1.45).