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The distribution and function of phosphatidylserine in cellular membranes.

Annual review of biophysics (2010-03-03)
Peter A Leventis, Sergio Grinstein
RÉSUMÉ

Phosphatidylserine (PS) is the most abundant negatively charged phospholipid in eukaryotic membranes. PS directs the binding of proteins that bear C2 or gamma-carboxyglutamic domains and contributes to the electrostatic association of polycationic ligands with cellular membranes. Rather than being evenly distributed, PS is found preferentially in the inner leaflet of the plasma membrane and in endocytic membranes. The loss of PS asymmetry is an early indicator of apoptosis and serves as a signal to initiate blood clotting. This review discusses the determinants and functional implications of the subcellular distribution and membrane topology of PS.

MATÉRIAUX
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Description du produit

Avanti
18:1 PS (DOPS), Avanti Research - A Croda Brand
Avanti
18:1 PS (DOPS), Avanti Research - A Croda Brand
Avanti
16:0-18:1 PS (POPS), Avanti Research - A Croda Brand
Avanti
16:0-18:1 PS (POPS), Avanti Research - A Croda Brand
Avanti
18:0 PS, Avanti Research - A Croda Brand
Avanti
16:0 PS, Avanti Research - A Croda Brand
Avanti
14:0 PS, Avanti Research - A Croda Brand
Avanti
18:1 NBD PS, Avanti Research - A Croda Brand 810198C
Avanti
18:2 PS, 1,2-dilinoleoyl-sn-glycero-3-phospho-L-serine (sodium salt), powder
Avanti
18:0-18:1 PS, 1-stearoyl-2-oleoyl-sn-glycero-3-phospho-L-serine (sodium salt), chloroform
Avanti
06:0 PS, 1,2-dihexanoyl-sn-glycero-3-phospho-L-serine (sodium salt), powder
Avanti
08:0 PS, 1,2-dioctanoyl-sn-glycero-3-phospho-L-serine (sodium salt), powder
Avanti
17:0 PS, Avanti Research - A Croda Brand
Avanti
18:0-18:1 PS, 1-stearoyl-2-oleoyl-sn-glycero-3-phospho-L-serine (sodium salt), powder
Avanti
18:0-18:2 PS, 1-stearoyl-2-linoleoyl-sn-glycero-3-phospho-L-serine (sodium salt), powder
Avanti
16:0-06:0 NBD PS, Avanti Research - A Croda Brand 810192C
Avanti
TopFluor PS, Avanti Research - A Croda Brand 810283P, powder
Avanti
TopFluor PS, Avanti Research - A Croda Brand 810283C
Avanti
12:0 PS, 1,2-dilauroyl-sn-glycero-3-phospho-L-serine (sodium salt), powder
Avanti
18:1-12:0 NBD PS, Avanti Research - A Croda Brand 810195C
Avanti
18:0-20:4 PS, 1-stearoyl-2-arachidonoyl-sn-glycero-3-phospho-L-serine (sodium salt), chloroform
Avanti
4ME 16:0 PS, 1,2-diphytanoyl-sn-glycero-3-phospho-L-serine (sodium salt), powder
Avanti
18:0-22:6 PS, 1-stearoyl-2-docosahexaenoyl-sn-glycero-3-phospho-L-serine (sodium salt), chloroform
Avanti
16:0-12:0 NBD PS, Avanti Research - A Croda Brand 810193C
Avanti
18:1-06:0 NBD PS, Avanti Research - A Croda Brand
Avanti
16:0-20:4 PS, 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phospho-L-serine (sodium salt), chloroform
Avanti
16:0-18:2 PS, 1-palmitoyl-2-linoleoyl-sn-glycero-3-phospho-L-serine (sodium salt), chloroform
Avanti
06:0 PS, 1,2-dihexanoyl-sn-glycero-3-phospho-L-serine (sodium salt), chloroform
Avanti
16:0-06:0 NBD PS, Avanti Research - A Croda Brand 810192P, powder
Avanti
18:0-18:2 PS, 1-stearoyl-2-linoleoyl-sn-glycero-3-phospho-L-serine (sodium salt), chloroform