1097909
USP
Cefotaxime sodium
United States Pharmacopeia (USP) Reference Standard
Synonyme(s) :
Cefotaxime sodium salt, Cefotaxim sodium salt
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About This Item
Formule empirique (notation de Hill):
C16H16N5NaO7S2
Numéro CAS:
Poids moléculaire :
477.45
Numéro Beilstein :
5711411
Numéro MDL:
Code UNSPSC :
41116107
ID de substance PubChem :
Nomenclature NACRES :
NA.24
Produits recommandés
Qualité
pharmaceutical primary standard
Famille d'API
cefotaxime
Fabricant/nom de marque
USP
Application(s)
pharmaceutical (small molecule)
Format
neat
Température de stockage
2-8°C
Chaîne SMILES
[Na+].[H][C@]12SCC(COC(C)=O)=C(N1C(=O)[C@H]2NC(=O)C(=N/OC)\c3csc(N)n3)C([O-])=O
InChI
1S/C16H17N5O7S2.Na/c1-6(22)28-3-7-4-29-14-10(13(24)21(14)11(7)15(25)26)19-12(23)9(20-27-2)8-5-30-16(17)18-8;/h5,10,14H,3-4H2,1-2H3,(H2,17,18)(H,19,23)(H,25,26);/q;+1/p-1/b20-9-;/t10-,14-;/m1./s1
Clé InChI
AZZMGZXNTDTSME-JUZDKLSSSA-M
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Description générale
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.
Application
- Rapid evolutionary change in trait correlations of single proteins: This article explores the rapid evolutionary changes in protein traits, providing a fundamental understanding that can inform biochemical studies using tools like Cefotaxime sodium to influence protein interactions in bacterial cells, enhancing the effectiveness of antibacterial therapies (Dasmeh et al., 2024).
- Moringa oleifera as a potential antimicrobial against pathogenic Clostridium perfringens isolates in farm animals: Research investigates the antimicrobial properties of Moringa oleifera, with implications for enhancing the efficacy of antibiotic treatments like Cefotaxime sodium in combating bacterial infections in veterinary applications (Ibrahim and Altammar, 2024).
- In vitro antibacterial activity of antibiotics and plant essential oils against Escherichia coli MTCC443 supported through the molecular docking and pharmacokinetics study: This study examines the synergistic effects of Cefotaxime sodium with plant essential oils against E. coli, highlighting its potential in developing new antibacterial combinations that enhance drug efficacy and reduce resistance (Jain et al., 2024).
- Efficacy and safety of antibiotics for treatment of leptospirosis: a systematic review and network meta-analysis: This comprehensive review assesses the effectiveness of Cefotaxime sodium among other antibiotics in treating leptospirosis, offering critical insights into its clinical utility and safety profile (Ji et al., 2024).
- Changing Landscape of Antimicrobial Resistance in Neonatal Sepsis: An in silico Analyses of Multidrug Resistance in Klebsiella pneumoniae: The study discusses the rising challenge of antibiotic resistance, emphasizing the role of Cefotaxime sodium in treating complex cases of neonatal sepsis, thus underlining the need for continuous research into its mechanisms and resistance patterns (Vijayakumar et al., 2024).
Actions biochimiques/physiologiques
Cefotaxim inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs) which inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell walls. As a result, bacteria lyse due to cell wall autolytic enzymes.
Autres remarques
Broad spectrum third generation cephalosporin antibiotic.
Sales restrictions may apply.
Remarque sur l'analyse
These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.
Produit(s) apparenté(s)
Réf. du produit
Description
Tarif
Mention d'avertissement
Danger
Mentions de danger
Conseils de prudence
Classification des risques
Resp. Sens. 1 - Skin Sens. 1
Code de la classe de stockage
11 - Combustible Solids
Classe de danger pour l'eau (WGK)
WGK 2
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Certificats d'analyse (COA)
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We describe the first case of treatment failure of gonorrhoea with a third generation cephalosporin, cefotaxime 1g intramuscularly, in the Netherlands. The case was from a high-frequency transmitting population (men having sex with men) and was caused by the internationally
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