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T0178

Sigma-Aldrich

apo-Transferrin bovine

≥98%

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About This Item

Numéro CAS:
11096-37-0
Numéro CE :
234-318-8
Numéro MDL:
MFCD00130536
Code UNSPSC :
12352202
Nomenclature NACRES :
NA.61

Source biologique

bovine

Pureté

≥98%

Forme

powder

Technique(s)

cell culture | mammalian: suitable

Solubilité

H2O: 20 mg/mL

Numéro d'accès UniProt

Q29443

Température de stockage

2-8°C

Informations sur le gène

bovine ... TF(280705)

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Application

All cells require iron for the proper uptake of oxygen from their environment. Transferrin, a protein isolated from serum, causes the uptake and transport of iron from culture medium to the cells. This allows proper oxygen uptake and also stimulates growth-related enzyme activity. Iron-saturated transferrin (holo transferrin) is continually recycled after releasing iron and becomes iron-deficient transferrin (apo-transferrin). Choosing which form to use depends upon the culture conditions. In media such as Dulbecco′s Modified Eagle′s Medium/Ham′s Nutrient Mixture F12 (DMEM/F12) that contain high levels of iron salt, using apo-transferrin is preferred.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

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Sandeep Kumar et al.
The journal of physical chemistry. B, 121(37), 8669-8683 (2017-08-25)
The macromolecular crowding influences the structural stability and functional properties of transferrin (Tf). The equilibrium as well as kinetic studies of Tf at different concentrations of crowding agents (dextran 40, dextran 70, and ficoll 70) and at a fixed concentration
Pablo Di Giusto et al.
Cells, 11(8) (2022-04-24)
The transcription factor CREB3L1 is expressed in a wide variety of tissues including cartilage, pancreas, and bone. It is located in the endoplasmic reticulum and upon stimulation is transported to the Golgi where is proteolytically cleaved. Then, the N-terminal domain
Elisabeth Wyart et al.
EMBO reports, 23(4), e53746-e53746 (2022-02-25)
Cachexia is a wasting syndrome characterized by devastating skeletal muscle atrophy that dramatically increases mortality in various diseases, most notably in cancer patients with a penetrance of up to 80%. Knowledge regarding the mechanism of cancer-induced cachexia remains very scarce
Min Lin et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 36(40), 10376-10391 (2016-10-07)
Methamphetamine (METH) is a substrate for the dopamine transporter that increases extracellular dopamine levels by competing with dopamine uptake and increasing reverse transport of dopamine via the transporter. METH has also been shown to alter the excitability of dopamine neurons.
J L Hayworth et al.
Clinical and experimental immunology, 157(1), 60-70 (2009-08-08)
Staphylococcal enterotoxin B (SEB) is a pyrogenic exotoxin and a potent superantigen which causes massive T cell activation and cytokine secretion, leading to profound immunosuppression and morbidity. The inhibition of SEB-induced responses is thus considered a goal in the management

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