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SRP3329

Sigma-Aldrich

EGF from mouse

Animal-component free, recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC)

Synonyme(s) :

URG, Urogastrone

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About This Item

Code UNSPSC :
12352202
Nomenclature NACRES :
NA.32

Source biologique

mouse

Produit recombinant

expressed in E. coli

Pureté

≥98% (HPLC)
≥98% (SDS-PAGE)

Forme

lyophilized

Puissance

≥1x10^7 units/mg

Poids mol.

6.0 kDa

Conditionnement

pkg of 500 μg

Impuretés

endotoxin, tested

Numéro d'accès UniProt

P01133

Conditions d'expédition

wet ice

Température de stockage

−20°C

Informations sur le gène

mouse ... EGF(13645)

Catégories apparentées

Description générale

Epidermal growth factor (EGF) is a potent growth factor that stimulates the proliferation of various epidermal and epithelial cells. The gene encoding this protein is localized on mouse chromosome 3. Recombinant murine EGF is a 6.0kDa globular protein containing 53 amino acid residues, including three intramolecular disulfide-bonds.

Actions biochimiques/physiologiques

Epidermal growth factor (EGF) has been shown to inhibit gastric secretion, and to be involved in wound healing. EGF signals through a receptor known as c-erbB, which is a class I tyrosine kinase receptor. This receptor also binds with transforming growth factor-α (TGF-α) and VGF (vaccinia virus growth factor). Injection of EGF into neonatal and adult rats has been shown to induce neurobehavioral deficits related to schizophrenia.

Forme physique

Lyophilized from 10 mM Sodium Phosphate, pH 8.5.

Reconstitution

Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.5-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.

Code de la classe de stockage

13 - Non Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

Epidermal growth factor therapy and wound healing--past, present and future perspectives.
Hardwicke J
The Surgeon : Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland, 6(3), 172-177 (2008)
Reactive oxygen species (ROS) are essential mediators in epidermal growth factor (EGF)-stimulated corneal epithelial cell proliferation, adhesion, migration, and wound healing.
Huo Y
Experimental Eye Research, 89(6), 876-886 (2009)
Wei Tu et al.
Journal of cellular and molecular medicine, 25(11), 5220-5237 (2021-05-06)
MicroRNAs have emerged as essential regulators in the biological process of liver regeneration by modulating the post-transcriptional expression of the target genes. In the present study, we found miR-20a expression is decreased remarkably in three rodent liver regeneration models using
Transforming growth factor alpha and epidermal growth factor in protection and healing of gastric mucosal injury.
Konturek SJ
Scandinavian Journal of Gastroenterology, 27(8), 649-655 (1992)
Gene for lymphoid enhancer-binding factor 1 (LEF1) mapped to human chromosome 4 (q23-q25) and mouse chromosome 3 near Egf.
Milatovich A
Genomics, 11(4), 1040-1048 (1991)
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